Florea Anca V, Ionescu Diana N, Melhem Mona F
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Arch Pathol Lab Med. 2007 May;131(5):799-804. doi: 10.5858/2007-131-799-PBIITI.
Human parvovirus B19 is a single-stranded DNA virus with a predilection for infecting rapidly dividing cell lines, such as bone marrow erythroid progenitor cells. People with defective cell-mediated immunity (eg, severe combined immunodeficiency syndrome; acquired immunodeficiency syndrome; and patients receiving immunosuppressive therapy, ie, post organ transplant) can develop pure red cell aplasia, in which suppression of erythroid precursors is permanent. Identification of parvovirus inclusions in marrow biopsies and subsequent confirmation of infection by in situ hybridization is important in the assessment of anemia in immunodeficient patients. Our objective is to provide a general overview of the parvovirus B19 infection and its characteristics in immunocompromised patients and to summarize updated information regarding the clinicopathologic features, pathobiology, and laboratory diagnosis of this subject. The pathologist should be aware of the wide spectrum of manifestations of parvovirus B19 infection depending on the patient's hematologic and immunologic status.
人细小病毒B19是一种单链DNA病毒，倾向于感染快速分裂的细胞系，如骨髓红系祖细胞。细胞介导免疫缺陷的人（如严重联合免疫缺陷综合征、获得性免疫缺陷综合征患者，以及接受免疫抑制治疗的患者，即器官移植后患者）可发生纯红细胞再生障碍，其中红系前体细胞的抑制是永久性的。在骨髓活检中鉴定细小病毒包涵体并随后通过原位杂交确认感染，对于评估免疫缺陷患者的贫血很重要。我们的目的是概述细小病毒B19感染及其在免疫受损患者中的特征，并总结有关该主题的临床病理特征、病理生物学和实验室诊断的最新信息。病理学家应意识到，根据患者的血液学和免疫状态，细小病毒B19感染有广泛的表现形式。
