Akimoto Y, Tanaka S, Omata H, Shibutani J, Nakano Y, Kaneko K, Kawana T, Teshigawara H, Nakao S, Fujii A
Second Department of Oral Surgery, Nihon University school of Dentistry, Matsudo, Japan.
J Nihon Univ Sch Dent. 1991 Sep;33(3):174-81. doi: 10.2334/josnusd1959.33.174.
We describe 4 cases of gingival hyperplasia induced by nifedipine, together with clinical and histological findings. Hyperplasia of the interdental papillae was observed in all cases. Histologic examination showed multilayered epithelial parakeratosis with variations in the width, proliferation, reticulation and elongation of the rete pegs. Substitution of another drug and improvement of oral hygiene led to reduction of the gingival overgrowth without gingivectomy. These treatments are essential for gingival hyperplasia induced by nifedipine.
我们描述了4例由硝苯地平引起的牙龈增生病例，以及临床和组织学检查结果。所有病例均观察到牙间乳头增生。组织学检查显示上皮不全角化， rete钉的宽度、增殖、网状结构和伸长存在差异。更换另一种药物并改善口腔卫生可在不进行牙龈切除术的情况下使牙龈过度生长减轻。这些治疗方法对于硝苯地平引起的牙龈增生至关重要。
