Guh Jinn-Yuh, Chen Hung-Chun, Tsai Jung-Fa, Chuang Lea-Yea
Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Am J Clin Nutr. 2007 May;85(5):1229-35. doi: 10.1093/ajcn/85.5.1229.
Betel quid (Areca catechu) is used by approximately 10% of the world population. Betel-quid use is associated with the metabolic syndrome--a risk factor for heart disease.
The objective was to test whether betel-quid use is associated with heart disease in adults.
Nonpregnant adults aged 20-64 y (n=1932, 52% women) from the nationally representative Nutrition and Health Survey in Taiwan (1993-1996) were studied for independent associations between betel-quid use and heart disease after adjustment for lifestyle factors, age, obesity, diabetes mellitus, hypertension, and concentrations of serum total cholesterol and HDL cholesterol.
The prevalence of betel-quid use was higher in men than in women (31% compared with 2.4%; P<0.001). The prevalence of heart disease was not significantly different between men and women (3.3% compared with 2.3%; P=0.12). The prevalence of betel-quid use decreased, whereas the prevalence of heart disease increased, with age. Betel-quid users were younger, drank more, had a lower dietary fruit intake, had a higher Framingham risk score, and had higher serum triacylglycerol concentrations than did the nonusers. At a mean consumption rate of 10 times/d (the third quartile of betel-quid consumption in betel-quid users), betel-quid use was independently associated with the Framingham risk score in subjects without heart disease only if obesity was not included as an adjustment factor (P=0.007). Moreover, the daily rate of betel-quid use was independently associated with prevalent heart disease; the odds ratio associated with a betel-quid consumption rate of 10 times/d was 1.37 (95% CI: 1.1, 1.6; P=0.003) in women.
Betel-quid use is independently associated with heart disease in women.
全世界约10%的人口嚼食槟榔（槟榔属植物）。嚼食槟榔与代谢综合征相关，而代谢综合征是心脏病的一个危险因素。
旨在检验嚼食槟榔是否与成年人的心脏病相关。
对来自具有全国代表性的台湾地区营养与健康调查（1993 - 1996年）的1932名20 - 64岁非孕成年人（52%为女性）进行研究，在对生活方式因素、年龄、肥胖、糖尿病、高血压以及血清总胆固醇和高密度脂蛋白胆固醇浓度进行校正后，分析嚼食槟榔与心脏病之间的独立关联。
男性嚼食槟榔的患病率高于女性（31%对比2.4%；P<0.001）。男性和女性的心脏病患病率无显著差异（3.3%对比2.3%；P = 0.12）。嚼食槟榔的患病率随年龄增长而下降，而心脏病患病率随年龄增长而上升。与不嚼食槟榔者相比，嚼食槟榔者更年轻，饮酒更多，饮食中水果摄入量更低，弗雷明汉风险评分更高，血清三酰甘油浓度更高。仅在不将肥胖作为校正因素时，对于无心脏病的受试者，以每天平均食用10次（嚼食槟榔者中槟榔食用量的第三个四分位数）的食用率嚼食槟榔与弗雷明汉风险评分独立相关（P = 0.007）。此外，每天嚼食槟榔的频率与现患心脏病独立相关；在女性中，每天嚼食槟榔10次的食用率对应的优势比为1.37（95%CI：1.1，1.6；P = 0.003）。
嚼食槟榔与女性的心脏病独立相关。
