Vasanthi V, Thavarajah Rooban, Rao Umadevi K, Joshua Elizabeth, Ranganathan Kannan
Department of Oral and Maxillofacial Pathology, Ragas Dental College and Hospital, Uthandi, Chennai, Tamil Nadu, India.
J Oral Maxillofac Pathol. 2022 Oct-Dec;26(4):447-450. doi: 10.4103/jomfp.jomfp_439_21. Epub 2022 Dec 22.
Chewing of areca nut is associated with various oral and systemic ill effects. The deleterious oral effects of areca nut have been widely documented to range from reactive lesions, periodontal health compromise to oral pre-cancer and cancerous states and have been described widely in the literature. The reported systemic effects of areca nut chewing are relatively less documented but reported in literature. Areca nut chewing may predispose to cardiovascular disease due to a systemic inflammatory response from the elevated levels of circulating inflammatory mediators. High-sensitivity C-reactive protein (hsCRP) is a systemic inflammatory biomarker to assess the risk of cardiovascular disease.
This cross-sectional, observational study was conducted among areca nut chewers ( = 50) and non-chewers ( = 50). Areca nut chewers were considered as chewers/cases. Blood samples were collected from the participants and hsCRP levels were studied. The data were analysed using SPSS software, version 21 for statistical significance. Chi-square test was used to compare categorical variables. Mann-Whitney test was done to analyse continuous variables. The level of statistical significance was set at value < 0.05.
hsCRP mean was higher among the chewers (2.3 ± 3.7) compared to non-chewers (0.9 ± 1.3). The difference in hsCRP levels between the study group was statistically significant ( = 0.002).
This study demonstrates the link between areca nut and cardiovascular disease using hsCRP as biomarker.
嚼槟榔与多种口腔和全身不良影响相关。槟榔的有害口腔影响已被广泛记录，范围从反应性病变、牙周健康受损到口腔癌前病变和癌变状态，并且在文献中已有广泛描述。槟榔咀嚼的全身影响报道相对较少，但文献中也有提及。由于循环炎症介质水平升高引发的全身炎症反应，嚼槟榔可能易患心血管疾病。高敏C反应蛋白（hsCRP）是评估心血管疾病风险的一种全身炎症生物标志物。
本横断面观察性研究在50名槟榔咀嚼者和50名非咀嚼者中进行。槟榔咀嚼者被视为咀嚼者/病例组。从参与者采集血样并研究hsCRP水平。使用SPSS 21版软件分析数据以确定统计学意义。卡方检验用于比较分类变量。曼-惠特尼U检验用于分析连续变量。统计学显著性水平设定为P值<0.05。
与非咀嚼者（0.9±1.3）相比，咀嚼者的hsCRP均值更高（2.3±3.7）。研究组之间hsCRP水平的差异具有统计学意义（P=0.002）。
本研究以hsCRP作为生物标志物，证明了槟榔与心血管疾病之间的联系。
