• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Effect of convulsions and anticonvulsive drugs on cerebrospinal fluid cyclic AMP in rabbits.

作者信息

Myllylä V V

出版信息

Eur Neurol. 1976;14(2):97-107. doi: 10.1159/000114732.

DOI:10.1159/000114732
PMID:174917
Abstract

Cyclic adenosine 3',5'-monophosphate (cAMP) concentration and aspartate amino transferase (ASAT or GOT) activity were measured from cerebrospinal fluid (CSF) of rabbits before and after electrically induced convulsions. The convulsions caused a significant increase in CSF cAMP concentration. The treatment with phenobarbital, diphenylhydantoin and carbamazepine for 7 days decreased the basal cAMP values in CSF and partly inhibited the rise after the convulsions. The alterations in ASAT activity were parallel, but less striking. The present results suggest the involvement of cAMP in epileptic discharge and in the mechanism of action of anticonvulsants.

摘要

相似文献

1
Effect of convulsions and anticonvulsive drugs on cerebrospinal fluid cyclic AMP in rabbits.
Eur Neurol. 1976;14(2):97-107. doi: 10.1159/000114732.
2
Cyclic AMP accumulation in cerebral cortical slices: effect of carbamazepine, phenobarbital, and phenytoin.大脑皮质切片中环磷酸腺苷的积累：卡马西平、苯巴比妥和苯妥英的作用。
Epilepsia. 1977 Jun;18(2):237-42. doi: 10.1111/j.1528-1157.1977.tb04472.x.
3
Effect of cerebral injury on cerebrospinal fluid cyclic AMP concentration.脑损伤对脑脊液环磷酸腺苷浓度的影响。
Eur Neurol. 1976;14(6):413-25. doi: 10.1159/000114768.
4
Anticonvulsant drug actions on in vitro and in vivo levels of cyclic AMP in the mouse brain.
Epilepsia. 1979 Apr;20(2):95-104. doi: 10.1111/j.1528-1157.1979.tb04782.x.
5
Anticonvulsant drug antagonism of delta9tetrahydrocannabinol-induced seizures in rabbits.抗惊厥药物对兔体内Δ⁹-四氢大麻酚诱发癫痫发作的拮抗作用。
Res Commun Chem Pathol Pharmacol. 1977 Jan;16(1):1-13.
6
[Changes in the cerebrospinal fluid levels of adenosine cyclic- 3',5'-monophosphate (c-AMP) in patients with generalized tonic-clonic epileptic seizures].
Neurol Neurochir Pol. 1991 May-Jun;25(3):332-6.
7
Cyclic amp concentration and enzyme activities of cerebrospinal fluid in patients with epilepsy or central nervous system damage.
Eur Neurol. 1975;13(2):123-30. doi: 10.1159/000114668.
8
Reduced taurine contents and modification of anticonvulsive effects of phenobarbital and phenytoin by guanidinoethane sulfonate in mice.
Prog Clin Biol Res. 1985;179:425-34.
9
Cerebrospinal fluid concentration of cyclic AMP in cerebrovascular diseases.脑血管疾病中脑脊液环磷酸腺苷的浓度
Eur Neurol. 1976;14(2):129-37. doi: 10.1159/000114735.
10
Changes in amino-acid neurotransmitters and cAMP in cerebral-spinal fluid from children and rabbits with epilepsy and convulsions.
Chin Med J (Engl). 1985 Oct;98(10):759-64.

引用本文的文献

1
Mechanisms of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024.卡马西平及其衍生物奥卡西平、BIA 2-093和BIA 2-024的作用机制。
Neurochem Res. 2002 Feb;27(1-2):121-30. doi: 10.1023/a:1014814924965.
2
The effect of ECT on plasma cyclic nucleotides: a simulated ECT controlled study in melancholic patients.电休克疗法对血浆环核苷酸的影响：一项针对忧郁症患者的模拟电休克对照研究。
Eur Arch Psychiatry Neurol Sci. 1990;239(6):343-6. doi: 10.1007/BF01734539.