来自紫伪瓜参的细胞毒性三萜糖苷。

Cytotoxic triterpene glycosides from the sea cucumber Pseudocolochirus violaceus.

作者信息

Zhang Shu-Yu, Tang Hai-Feng, Yi Yang-Hua

机构信息

Research Center for Marine Drugs, College of Pharmacy, 2nd Military Medical University, Shanghai 200433, PR China.

出版信息

Fitoterapia. 2007 Jun;78(4):283-7. doi: 10.1016/j.fitote.2007.02.010. Epub 2007 Apr 11.

DOI:10.1016/j.fitote.2007.02.010

PMID:17493770

Abstract

A new triterpene glycoside (1) along with the known intercedenside B (2) was isolated from the sea cucumber Pseudocolochirus violaceus. Glycoside 1 was elucidated as 3-O-{6-O-sodiumsulfate-3-O-methyl-beta-D-glucopyranosyl-(1-->3)-beta-D-xylopyranosyl-(1-->4)-[beta-D-xylopyranosyl(1-->2)]-beta-D-quinovopyranosyl-(1-->2)-4-O-sodiumsulfate-beta-D-xylopyranosyl}-16beta-acetoxy-holosta-7, 24-diene-3beta-ol on the basis of extensive spectral studies and chemical evidence. Both the glycosides exhibited significant cytotoxicity against cancer cell lines MKN-45 and HCT-116.

摘要

从紫伪海棒槌中分离得到一个新的三萜糖苷（1）以及已知的intercedenside B（2）。基于广泛的光谱研究和化学证据，糖苷1被鉴定为3-O-{6-O-硫酸钠-3-O-甲基-β-D-吡喃葡萄糖基-(1→3)-β-D-吡喃木糖基-(1→4)-[β-D-吡喃木糖基(1→2)]-β-D-奎诺吡喃糖基-(1→2)-4-O-硫酸钠-β-D-吡喃木糖基}-16β-乙酰氧基-胆甾-7,24-二烯-3β-醇。这两种糖苷对癌细胞系MKN-45和HCT-116均表现出显著的细胞毒性。