来自紫伪翼手参的两种新型生物活性三萜糖苷。

Two new bioactive triterpene glycosides from the sea cucumber Pseudocolochirus violaceus.

作者信息

Zhang Shu-Yu, Yi Yang-Hua, Tang Hai-Feng, Li Ling, Sun Peng, Wu Jun

机构信息

School of Pharmacy, Second Military Medical University, Research Centre for Marine Drugs, Shanghai 200433, China.

出版信息

J Asian Nat Prod Res. 2006 Jan-Mar;8(1-2):1-8. doi: 10.1080/10286020500034972.

DOI:10.1080/10286020500034972

PMID:16753775

Abstract

By activity-guided fractionation, two new triterpene glycosides, violaceusides A (1) and B (2), were isolated from the sea cucumber Pseudocolochirus violaceus as active compounds causing morphological abnormality of Pyricularia oryzae mycelia. By extensive 2D NMR techniques and chemical evidence, the structures of the two new glycosides were established as 16beta-acetoxy-3-O-[3-O-methyl-beta-D-glucopyranosyl-(1 --> 3)-beta-D-xylopyranosyl-(1 --> 4)-beta-D-quinovopyranosyl-(1 --> 2)-4-O-sodiumsulphate-beta-D-xylopyranosyl]-holosta-7,24-diene-3beta-ol (1) and 16beta-acetoxy-3-O-[3-O-methyl-beta-D-glucopyranosyl-(1 --> 3)-beta-D-xylopyranosyl-(1 --> 4)-beta-D-glucopyranosyl-(1 --> 2)-4-O-sodiumsulphate-beta-D-xylopyranosyl]-holosta-7,24-diene-3beta-ol (2), respectively. The two glycosides also exhibited significant cytotoxicity against HL-60 and BEL-7402 cancer cell lines.

摘要

通过活性导向分离，从海参紫伪锚参中分离出两种新的三萜糖苷，即紫苷A（1）和紫苷B（2），它们是导致稻瘟病菌丝体形态异常的活性化合物。通过广泛的二维核磁共振技术和化学证据，确定这两种新糖苷的结构分别为16β-乙酰氧基-3-O-[3-O-甲基-β-D-吡喃葡萄糖基-(1→3)-β-D-吡喃木糖基-(1→4)-β-D-奎诺吡喃糖基-(1→2)-4-O-硫酸钠盐-β-D-吡喃木糖基]-全甾-7,24-二烯-3β-醇（1）和16β-乙酰氧基-3-O-[3-O-甲基-β-D-吡喃葡萄糖基-(1→3)-β-D-吡喃木糖基-(1→4)-β-D-吡喃葡萄糖基-(1→2)-4-O-硫酸钠盐-β-D-吡喃木糖基]-全甾-7,24-二烯-3β-醇（2）。这两种糖苷对HL-60和BEL-7402癌细胞系也表现出显著的细胞毒性。