呼吸道合胞病毒小疏水蛋白的功能。
Function of the respiratory syncytial virus small hydrophobic protein.
作者信息
Fuentes Sandra, Tran Kim C, Luthra Priya, Teng Michael N, He Biao
机构信息
Center of Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, 115 Henning Bldg., University Park, PA 16802, USA.
出版信息
J Virol. 2007 Aug;81(15):8361-6. doi: 10.1128/JVI.02717-06. Epub 2007 May 9.
Abstract
Respiratory syncytial virus (RSV), a member of the Paramyxoviridae family, encodes a small hydrophobic (SH) protein of unknown function. Parainfluenza virus 5 (PIV5), a prototypical paramyxovirus, also encodes an SH protein, which inhibits tumor necrosis factor alpha (TNF-alpha) signaling. In this study, recombinant PIV5 viruses without their own SH but containing RSV SH (from RSV strain A2 or B1) in its place (PIV5DeltaSH-RSV SH) and RSV lacking its own SH (RSVDeltaSH) were generated and analyzed. The results indicate that the SH protein of RSV has a function similar to that of PIV5 SH and that it can inhibit TNF-alpha signaling.
摘要
呼吸道合胞病毒（RSV）是副粘病毒科的成员，编码一种功能未知的小疏水（SH）蛋白。副流感病毒5型（PIV5）是一种典型的副粘病毒，也编码一种SH蛋白，该蛋白可抑制肿瘤坏死因子α（TNF-α）信号传导。在本研究中，构建并分析了缺失自身SH蛋白但在其位置含有RSV SH蛋白（来自RSV A2或B1株）的重组PIV5病毒（PIV5DeltaSH-RSV SH）以及缺失自身SH蛋白的RSV（RSVDeltaSH）。结果表明，RSV的SH蛋白具有与PIV5 SH蛋白相似的功能，并且它可以抑制TNF-α信号传导。
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The small hydrophobic (SH) protein accumulates within lipid-raft structures of the Golgi complex during respiratory syncytial virus infection.在呼吸道合胞病毒感染期间，小疏水（SH）蛋白在高尔基体复合体的脂筏结构内积聚。
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