一种用于测定先天性巨结肠症患者直肠活检组织中乙酰胆碱酯酶活性的改良方法。
An improved method for the determination of acetylcholinesterase activity in rectal biopsy tissue from patients with Hirschsprung's disease.
作者信息
Dale G, Bonham J R, Riley K W, Wagget J
出版信息
Clin Chim Acta. 1977 Jun 15;77(3):407-13. doi: 10.1016/0009-8981(77)90247-9.
PMID:17496
Abstract
A method is described for the assay of acetylcholinesterase in tissue samples using the selective cholinesterase inhibitor, lysivane (10-(alpha-diethylaminopropyl) phenothiazine hydrochloride). Significantly increased enzyme activity is found in rectal biopsy specimens from patients with Hirschsprung's disease (p less than 0.001) indicating the diagnostic usefulness of the assay.
摘要
本文描述了一种使用选择性胆碱酯酶抑制剂利西凡（10-(α-二乙氨基丙基)吩噻嗪盐酸盐）测定组织样本中乙酰胆碱酯酶的方法。在患有先天性巨结肠症的患者的直肠活检标本中发现酶活性显著增加（p<0.001），表明该测定法具有诊断价值。
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