肠道固有免疫与沙门氏菌肠炎的发病机制
Intestinal innate immunity and the pathogenesis of Salmonella enteritis.
作者信息
Srikanth Chittur V, Cherayil Bobby J
机构信息
Mucosal Immunology Laboratory, Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
出版信息
Immunol Res. 2007;37(1):61-78. doi: 10.1007/BF02686090.
Abstract
Acute gastroenteritis caused by Salmonella typhimurium infection is a clinical problem with significant public health impact. The availability of several experimental models of this condition has allowed detailed investigation of the cellular and molecular interactions involved in its pathogenesis. Such studies have shed light on the roles played by bacterial virulence factors and host innate immune mechanisms in the development of intestinal inflammation.
摘要
鼠伤寒沙门氏菌感染引起的急性肠胃炎是一个对公共卫生有重大影响的临床问题。针对这种病症的多种实验模型的出现，使得对其发病机制中涉及的细胞和分子相互作用进行详细研究成为可能。此类研究揭示了细菌毒力因子和宿主固有免疫机制在肠道炎症发展过程中所起的作用。
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