Gabillot-Carré Marion, Roujeau Jean-Claude
Hopital Henri Mondor, Créteil, France.
Curr Opin Infect Dis. 2007 Apr;20(2):118-23. doi: 10.1097/QCO.0b013e32805dfb2d.
Acute bacterial skin infections are very common, with various presentations and severity. This review focuses on deep skin infections. We separate acute nonnecrotizing infections of the hypodermis (erysipelas), forms with abscesses or exudates and necrotizing fasciitis. These three types actually differ in risk factors, bacteriology, treatment and prognosis.
Leg erysipelas/cellulitis occurs in more than one person/1000/year. It remains mainly due to streptococci. Foot intertrigo is an important risk factor. Necrotizing fasciitis is much rarer and usually occurs in patients with chronic diseases. Staphylococci, especially community-acquired methicillin-resistant strains in some areas, play a growing role in the intermediate form of cellulitis with abscesses and exudates. For erysipelas or noncomplicated cellulitis, antibiotic treatment at home, when feasible, is much less expensive and as effective as hospital treatment. Intermediate cases with collections and exudates often require surgical drainage. For necrotizing fasciitis early surgery remains essential in order to decrease the mortality rate.
Antibiotic treatment of deep skin infections must be active on streptococci; the choice of a larger spectrum of activity depends on clinical presentation, risk factors and the burden of methicillin-resistant staphylococci in the environment.
急性细菌性皮肤感染非常常见,表现形式和严重程度各异。本综述聚焦于深部皮肤感染。我们将皮下急性非坏死性感染(丹毒)、伴有脓肿或渗出物的形式以及坏死性筋膜炎区分开来。这三种类型在危险因素、细菌学、治疗和预后方面实际上存在差异。
腿部丹毒/蜂窝织炎的年发病率超过千分之一。其主要病因仍为链球菌。足部擦烂是一个重要的危险因素。坏死性筋膜炎更为罕见,通常发生在慢性病患者中。葡萄球菌,尤其是某些地区社区获得性耐甲氧西林菌株,在伴有脓肿和渗出物的蜂窝织炎中间形式中发挥着越来越大的作用。对于丹毒或非复杂性蜂窝织炎,在可行的情况下,在家中进行抗生素治疗成本要低得多,且与住院治疗效果相当。伴有积液和渗出物的中间型病例通常需要手术引流。对于坏死性筋膜炎,早期手术对于降低死亡率仍然至关重要。
深部皮肤感染的抗生素治疗必须对链球菌有活性;更广泛抗菌谱的选择取决于临床表现、危险因素以及环境中耐甲氧西林葡萄球菌的负担。