Petrov Maxim S, Gordetzov Alexander S, Emelyanov Nikolay V
Department of Surgery, Nizhny Novgorod State Medical Academy, Nizhny Novgorod, Russia.
ANZ J Surg. 2007 May;77(5):347-51. doi: 10.1111/j.1445-2197.2007.04057.x.
The lack of a gold standard for the diagnosis of acute pancreatitis remains a problem. Our aim was to evaluate whether infrared spectroscopy of serum can establish the diagnosis of acute pancreatitis.
Sixty-four patients with acute pancreatitis, 112 patients with non-pancreatic acute abdomen and 40 healthy subjects were studied. In addition to serum infrared spectral analysis, serum concentrations of amylase and lipase were measured on admission.
Infrared spectroscopy based on serum absorption patterns in the range 800-1000 nm successfully distinguished acute pancreatitis from acute abdominal disorders of extrapancreatic origin and from control specimens. The sensitivity, specificity and positive and negative predictive values of infrared spectroscopy on admission were 91, 91, 85, and 94%, respectively. Within 24 h of onset of symptoms, infrared spectroscopy, lipase and amylase showed similar areas under the ROC curves for infrared spectra of serum (0.93), lipase (0.96) and amylase (0.91).
The successful classification of infrared spectra in patients with acute pancreatitis implies that the pathophysiology of disease alters the composition of the specimen in a characteristic fashion--in this case the serum make-up reflects the presence of acute pancreatitis.
急性胰腺炎诊断缺乏金标准仍是一个问题。我们的目的是评估血清红外光谱是否能用于诊断急性胰腺炎。
研究了64例急性胰腺炎患者、112例非胰腺性急腹症患者和40名健康受试者。除血清红外光谱分析外，入院时还测定了血清淀粉酶和脂肪酶浓度。
基于800 - 1000 nm范围内血清吸收模式的红外光谱成功区分了急性胰腺炎与胰腺外源性急性腹部疾病及对照样本。入院时红外光谱的敏感性、特异性、阳性预测值和阴性预测值分别为91%、91%、85%和94%。在症状出现后24小时内，红外光谱、脂肪酶和淀粉酶在血清红外光谱（0.93）、脂肪酶（0.96）和淀粉酶（0.91）的ROC曲线下面积相似。
急性胰腺炎患者红外光谱的成功分类意味着疾病的病理生理学以一种特征性方式改变了样本的组成——在这种情况下，血清组成反映了急性胰腺炎的存在。
