Buck J, Derguini F, Levi E, Nakanishi K, Hämmerling U
Department of Immunology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
Science. 1991 Dec 13;254(5038):1654-6. doi: 10.1126/science.1749937.
In mammals, retinol is the precursor for retinoids, which affect various aspects of morphogenesis and development. However, B lymphocytes, although retinol-dependent, do not use retinoic acid as mediator. Retinol is metabolized by B lymphocytes and other cell lines to optically active 14-hydroxy-4,14-retro-retinol; it is this compound that mediates the growth control. Thus another second messenger molecule, in addition to retinoic acid and retinal, is derived from retinol.
在哺乳动物中，视黄醇是类视黄醇的前体，类视黄醇会影响形态发生和发育的各个方面。然而，B淋巴细胞虽然依赖视黄醇，但并不将视黄酸用作介质。视黄醇被B淋巴细胞和其他细胞系代谢为具有光学活性的14-羟基-4,14-反式视黄醇；正是这种化合物介导了生长控制。因此，除了视黄酸和视黄醛之外，另一种第二信使分子源自视黄醇。
