脱水视黄醇：一种天然存在的淋巴细胞生理抑制剂。
Anhydroretinol: a naturally occurring inhibitor of lymphocyte physiology.
作者信息
Buck J, Grün F, Derguini F, Chen Y, Kimura S, Noy N, Hämmerling U
机构信息
Department of Immunology, Memorial Sloan-Kettering Cancer Center, New York 10021.
出版信息
J Exp Med. 1993 Aug 1;178(2):675-80. doi: 10.1084/jem.178.2.675.
Abstract
Vitamin A (retinol) is an essential cofactor for growth of B lymphocytes in culture and for activation of T lymphocytes by antigen receptor-mediated signals. 14-hydroxy-4,14-retro-retinol (14-HRR) a metabolite of retinol, has been implicated as the intracellular mediator of this effect. Anhydroretinol (AR) is a retinol derivative with retro structure produced in activated human B lymphocytes and the insect cell lines SF 21 and Schneider S2. AR reversibly inhibits retinol- and 14-HRR-dependent effects and blocks B lymphocyte proliferation as well as activation of resting T lymphocytes. The intracellular signaling pathway blocked by AR in T cell activation is distinct from the calcineurin/interleukin 2 pathway inhibitable by cyclosporine A or FK-506.
摘要
维生素A（视黄醇）是培养中B淋巴细胞生长以及抗原受体介导信号激活T淋巴细胞所必需的辅助因子。视黄醇的一种代谢产物14-羟基-4,14-反式视黄醇（14-HRR）被认为是这种效应的细胞内介质。脱水视黄醇（AR）是一种具有反式结构的视黄醇衍生物，在活化的人B淋巴细胞以及昆虫细胞系SF 21和施奈德S2中产生。AR可逆地抑制视黄醇和14-HRR依赖性效应，并阻断B淋巴细胞增殖以及静止T淋巴细胞的激活。AR在T细胞激活中阻断的细胞内信号通路不同于可被环孢素A或FK-506抑制的钙调神经磷酸酶/白细胞介素2通路。
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