El Sayed Khalid A, Sylvester Paul W
University of Louisiana at Monroe, Department of Basic Pharmaceutical Sciences, College of Pharmacy, Monroe, Louisiana 71209, USA.
Expert Opin Investig Drugs. 2007 Jun;16(6):877-87. doi: 10.1517/13543784.16.6.877.
Historically, tobacco use was primarily recreational and has been smoked in cigarettes, cigars and pipes, as well as smokeless forms of consumption, all of which are associated with adverse health effects. However, recent scientific investigations indicate that tobacco also contains several diverse secondary metabolites that may provide potential health benefits in the treatment of cancer and neurodegenerative diseases. Specifically, the leaf and flower of Nicotiana tabacum contain high amounts of the key flavor ingredient, cembranoids. Tobacco alpha- and beta-2,7,11-cembratriene-4,6-diols display potent anticancer activity. These compounds have also been found to inhibit phorbol ester-stimulated (32)P(i) incorporation into phospholipids, induction of Epstein-Barr virus early antigen and protein phosphorylation. This review focuses on the biocatalytic and semisynthetic studies of tobacco cembanoids and their anticancer activity.
从历史上看，烟草的使用主要是用于消遣，人们通过香烟、雪茄、烟斗吸烟，以及采用无烟消费形式，所有这些都与不良健康影响有关。然而，最近的科学研究表明，烟草还含有几种不同的次生代谢产物，它们可能在癌症和神经退行性疾病的治疗中提供潜在的健康益处。具体而言，烟草的叶子和花朵含有大量关键风味成分——西柏烷类化合物。烟草α-和β-2,7,11-西柏三烯-4,6-二醇具有强大的抗癌活性。这些化合物还被发现可抑制佛波酯刺激的（32）P（i）掺入磷脂、抑制爱泼斯坦-巴尔病毒早期抗原的诱导和蛋白质磷酸化。本综述重点关注烟草西柏烷类化合物的生物催化和半合成研究及其抗癌活性。
