Aydin Erdinc, Demir Helin Deniz, Demirturk Fazli, Caliskan Ahmet Cantug, Aytan Hakan, Erkorkmaz Unal
Department of Ophthalmology, Gaziosmanpasa University Faculty of Medicine, Tokat, Turkey.
BMC Ophthalmol. 2007 May 14;7:9. doi: 10.1186/1471-2415-7-9.
To asses the effect of menopause on the corneal curvature changes using corneal computerized videokeratography (CVK) in premenopausal and postmenopausal healthy women.
Thirty-six postmenopausal women with mean ages of 49.2 (range 39 to 57) were enrolled in this randomized, prospective study, comparing with 26 healthy controls with mean ages of 38.5 +/- 4.9 (range 32 to 49). Subjects were determined to be postmenopausal, by the Gynecology and Obstetrics Department, based on blood Follicular Stimulating Hormone (FSH), Luteinizing Hormone (LH), Estradiol, Progesterone levels and clinical complaints. Complete ophthalmic examination and CVK using Haag-Streit System was performed in both premenopausal and postmenopausal women.
Mean horizontal curvature and vertical curvature of central corneal power in premenopausal women were 43.5 +/- 1.25 Diopter (D), and 44.1 +/- 1.53 D. Mean horizontal curvature and vertical curvature of central corneal power in postmenopausal women were 43.9 +/- 1.4 D, and 44.6 +/- 1.3 D. The mean keratometric astigmatisms of premenopausal and postmenopausal women were 0.81 +/- 0.57 D (4-179 degrees), 0.74 degrees +/- 0.5 D (1-180 degrees) respectively. No significant corneal curvature changes were detected between premenopausal and postmenopausal groups (P > 0.05). On the other hand, we only found negative but significant correlation between horizontal corneal curvature and estrogen level of postmenopausal women (r = -0.346, p = 0.038).
Menopause is physiologic process and may also affect corneal topographic changes. In postmenopausal women, corneal steeping was observed minimally compared to premenopausal women. The results suggest that changes in estrogen level of women with menopause are associated with slightly alteration of horizontal curvature of cornea.
使用角膜电脑摄像角膜曲率计（CVK）评估绝经对绝经前和绝经后健康女性角膜曲率变化的影响。
36名平均年龄为49.2岁（范围39至57岁）的绝经后女性被纳入这项随机前瞻性研究，与26名平均年龄为38.5±4.9岁（范围32至49岁）的健康对照者进行比较。妇产科根据血液卵泡刺激素（FSH）、黄体生成素（LH）、雌二醇、孕酮水平及临床症状确定受试者为绝经后。对绝经前和绝经后女性均进行了全面的眼科检查并使用Haag-Streit系统进行CVK检查。
绝经前女性中央角膜屈光力的平均水平曲率和垂直曲率分别为43.5±1.25屈光度（D）和44.1±1.53 D。绝经后女性中央角膜屈光力的平均水平曲率和垂直曲率分别为43.9±1.4 D和44.6±1.3 D。绝经前和绝经后女性的平均角膜散光分别为0.81±0.57 D（4 - 179度）、0.74度±0.5 D（1 - 180度）。绝经前和绝经后组之间未检测到显著的角膜曲率变化（P>0.05）。另一方面，我们仅发现绝经后女性水平角膜曲率与雌激素水平之间存在负相关但具有统计学意义（r = -0.346，p = 0.038）。
绝经是一个生理过程，也可能影响角膜地形图变化。与绝经前女性相比，绝经后女性角膜变陡程度最小。结果表明，绝经女性雌激素水平的变化与角膜水平曲率的轻微改变有关。
