Noor Ophthalmology Research Center, Noor Eye Hospital, Tehran, Iran.
Translational Ophthalmology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Sci Rep. 2024 Aug 26;14(1):19784. doi: 10.1038/s41598-024-70850-4.
To determine the distribution of keratometry and corneal astigmatism (CA) and their association with demographic factors, systemic parameters, anthropometric measures, ocular biometric indices, and refractive errors in people aged 60 years and above. In this cross-sectional study, 160 clusters were randomly selected from Tehran city (Iran) using the multi-stage cluster sampling method. All participants underwent optometric examinations including testing uncorrected and best-corrected distance visual acuity, non-cycloplegic autorefraction, and subjective refraction. Pentacam imaging for all participants was carried out using Pentacam AXL. Keratometry and CA were reported based on Pentacam's data. The average, standard deviation (SD) and 95% confidence interval (CI) of flat keratometry (Kf), steep keratometry (Ks), mean keratometry (mean K), and CA were 44.02 ± 1.58 D (95% CI 43.94-44.1), 44.86 ± 1.67 D (95% CI 44.78-44.94), 44.44 ± 1.58 D (95% CI 44.36-44.52), and 0.84 ± 0.74 D (95% CI 0.81-0.87), respectively. The 95% and 99% percentiles of mean K were 47.1 and 48.6 D, respectively. According to the multiple generalized estimating equation model, the mean K was significantly higher in males, in myopes, and in those with higher systolic blood pressure. Moreover, the mean K was inversely related to the axial length, height, anterior chamber depth (ACD), corneal diameter, and central corneal thickness (CCT). The prevalence of various types of CA based on a cut-off > 0.50 D was as follows; with-the-rule: 32.5% (95% CI 30.6-34.4), against-the-rule: 18.2% (95% CI 16.7-19.7), and oblique: 10.0% (95% CI 9.1-11.0). The present study investigated the normal distribution of keratometry and CA in individuals ≥ 60 years, and results can be used in clinical matters, especially in intraocular lens power calculation. Sex, systolic blood pressure, height, and some biometric components such as ACD, corneal diameter, and CCT were significantly related to keratometry and should be considered.
为了确定角膜曲率和角膜散光(CA)的分布及其与人口统计学因素、全身参数、人体测量指标、眼生物测量指数和屈光不正的关系,对 60 岁及以上人群进行了这项横断面研究。在这项研究中,采用多阶段聚类抽样法,从德黑兰市(伊朗)随机抽取了 160 个群集。所有参与者均接受了眼科检查,包括测试未经矫正和最佳矫正的远距视力、非睫状肌自动折射和主观折射。对所有参与者均使用 Pentacam AXL 进行 Pentacam 成像。基于 Pentacam 的数据报告角膜曲率和 CA。平角膜曲率(Kf)、陡角膜曲率(Ks)、平均角膜曲率(平均 K)和 CA 的平均值、标准差(SD)和 95%置信区间(CI)分别为 44.02±1.58 D(95%CI 43.94-44.1)、44.86±1.67 D(95%CI 44.78-44.94)、44.44±1.58 D(95%CI 44.36-44.52)和 0.84±0.74 D(95%CI 0.81-0.87)。平均 K 的 95%和 99%分位数分别为 47.1 和 48.6 D。根据多变量广义估计方程模型,男性、近视者和收缩压较高者的平均 K 较高。此外,平均 K 与眼轴长度、身高、前房深度(ACD)、角膜直径和中央角膜厚度(CCT)呈负相关。基于>0.50 D 截断值的各种类型 CA 的患病率如下:顺规性:32.5%(95%CI 30.6-34.4)、逆规性:18.2%(95%CI 16.7-19.7)和斜向性:10.0%(95%CI 9.1-11.0)。本研究调查了≥60 岁人群角膜曲率和 CA 的正常分布,结果可用于临床,特别是人工晶状体屈光力计算。性别、收缩压、身高以及 ACD、角膜直径和 CCT 等一些生物测量指标与角膜曲率显著相关,应予以考虑。