Shin Jeong Hwan, Jung Hee Jung, Kim Hye Ran, Jeong Joseph, Jeong Seok Hoon, Kim Sunjoo, Lee Eun Yup, Lee Jeong Nyeo, Chang Chulhun Ludgerus
Department of Laboratory Medicine, College of Medicine, Inje University, 633-165 Gaegeum-Dong Busanjin-Gu, Busan, 614-110, Korea.
Antimicrob Agents Chemother. 2007 Jul;51(7):2625-7. doi: 10.1128/AAC.00107-07. Epub 2007 May 14.
The genes erm(B), mef(A), and both erm(B) and mef(A) were identified in 42.6, 10.1, and 47.3%, respectively, of the erythromycin-resistant Streptococcus pneumoniae isolates. Of the strains, 3.8% were nonsusceptible to levofloxacin and had 1 to 6 amino acid changes in the quinolone resistance-determining region, including a new mutation, Asn94Ser, in the product of parC. Levofloxacin with reserpine was highly specific for efflux screening.
在对红霉素耐药的肺炎链球菌分离株中,分别有42.6%、10.1%和47.3%鉴定出erm(B)基因、mef(A)基因以及erm(B)和mef(A)两个基因。这些菌株中,3.8%对左氧氟沙星不敏感,在喹诺酮耐药决定区有1至6个氨基酸变化,包括parC产物中的一个新突变Asn94Ser。利血平存在时的左氧氟沙星对流出筛选具有高度特异性。