Greaves J L, Wilson C G, Galloway N R, Birmingham A T, Olejnik O
Department of Physiology & Pharmacology, Medical School, Queen's Medical Centre, Nottingham, Great Britain.
Acta Ophthalmol (Copenh). 1991 Aug;69(4):432-6. doi: 10.1111/j.1755-3768.1991.tb02018.x.
The precorneal residence of an artificial tear preparation has been compared in twelve patients with keratoconjunctivitis sicca (KCS) and twelve normal healthy volunteers. The artificial tear solution was radiolabelled by the inclusion of 1 MBq technetium-99m diethylenetriaminepentaacetic acid (99Tcm-DTPA), and 25 microliters was instilled into one eye only. Deposition of the preparation was followed by gamma scintigraphy. Precorneal clearance of the solution was found to follow bi-exponential kinetics in all subjects with no significant differences in clearance rates between the two study populations. There was also no significant difference in the area under the time-activity profile for the two study groups. This suggests that the reduced reflex tearing and basal lacrimation in KCS patients, indicated by the Schirmer's test, are not important in the clearance of isotonic solutions from the eye surface.
对12例干燥性角结膜炎（KCS）患者和12名正常健康志愿者的人工泪液制剂在角膜前的存留情况进行了比较。通过加入1MBq的锝-99m二乙三胺五乙酸（99Tcm-DTPA）对人工泪液进行放射性标记，仅向一只眼睛滴入25微升。通过γ闪烁扫描术追踪制剂的沉积情况。发现所有受试者中溶液的角膜前清除均遵循双指数动力学，两个研究人群之间的清除率无显著差异。两个研究组的时间-活性曲线下面积也无显著差异。这表明，由泪液分泌试验所显示的KCS患者反射性流泪减少和基础泪液分泌减少，在从眼表清除等渗溶液方面并不重要。
