Snibson G R, Greaves J L, Soper N D, Prydal J I, Wilson C G, Bron A J
Department of Ophthalmology, University of Oxford.
Eye (Lond). 1990;4 ( Pt 4):594-602. doi: 10.1038/eye.1990.83.
Sodium hyaluronate solutions have been advocated in the management of a variety of dry-eye states. By virtue of their non-Newtonian rheological properties, formulations exhibiting high zero-shear viscosities may be used as an artificial tear with the expectation of prolonged precorneal residence times and improved tolerance. Quantitative gamma scintigraphy was used to evaluate the residence times of 0.2% and 0.3% sodium hyaluronate solutions and a polymer-free solution of buffered saline in 12 patients with keratoconjunctivitis sicca and a group of six normal volunteers. Using several indices of residence time, mean values for the sodium hyaluronate solutions were significantly longer than those for buffered saline. Parallel changes in tear film thickness were also demonstrated using a technique based on laser interferometry.
透明质酸钠溶液已被推荐用于多种干眼状态的治疗。凭借其非牛顿流变学特性，具有高零剪切粘度的制剂可用作人工泪液，以期延长角膜前停留时间并提高耐受性。采用定量γ闪烁显像术评估了12例干燥性角结膜炎患者和一组6名正常志愿者使用0.2%和0.3%透明质酸钠溶液以及无聚合物的缓冲盐溶液后的停留时间。使用多种停留时间指标，透明质酸钠溶液的平均值显著长于缓冲盐溶液。还使用基于激光干涉测量的技术证明了泪膜厚度的平行变化。
