Granholm Eric, McQuaid John R, McClure Fauzia Simjee, Link Peter C, Perivoliotis Dimitri, Gottlieb Jennifer D, Patterson Thomas L, Jeste Dilip V
Veterans Affairs San Diego Healthcare System, San Diego, Calif 92161, USA.
J Clin Psychiatry. 2007 May;68(5):730-7. doi: 10.4088/jcp.v68n0510.
There is an increasing need for empirically validated psychotherapy interventions that improve functioning in older people with schizophrenia. We developed a 24-session weekly group therapy intervention labeled Cognitive Behavioral Social Skills Training (CBSST), which combined cognitive-behavioral therapy with social skills and problem-solving training to improve functioning.
We previously reported end-of-treatment findings from a randomized controlled trial that compared treatment as usual (TAU) with TAU plus group CBSST in 76 outpatients, 42 to 74 years of age, with schizophrenia or schizoaffective disorder (DSM-IV criteria). Twelve-month follow-up results of that trial (conducted from October 1999 to September 2004) are reported here. Blind raters obtained assessments of CBSST skill mastery, functioning, psychotic and depressive symptoms, and cognitive insight (belief flexibility).
The significantly greater skill acquisition and self-reported performance of living skills in the community seen in CBSST versus TAU patients at the end of treatment were maintained at 12-month follow-up (p < or = .05). Participants in CBSST also showed significantly greater cognitive insight at the end of treatment relative to TAU, but this improvement was not maintained at follow-up. The treatment-group effect was not significant for symptoms at any assessment point; however, symptoms were not the primary treatment target in this stable outpatient sample.
Older people with very chronic schizophrenia were able to learn and maintain new skills with CBSST and showed improved self-reported functioning 1 year after the treatment ended. Longer treatment and/or booster sessions may be required to maintain gains in cognitive insight.
对于经实证验证的、能改善老年精神分裂症患者功能的心理治疗干预措施的需求日益增加。我们开发了一种为期24节、每周一次的团体治疗干预方法,称为认知行为社交技能训练(CBSST),它将认知行为疗法与社交技能及问题解决训练相结合以改善功能。
我们之前报告了一项随机对照试验的治疗结束时的结果,该试验将常规治疗(TAU)与TAU加团体CBSST相比较,受试对象为76名年龄在42至74岁之间、患有精神分裂症或分裂情感性障碍(符合《精神疾病诊断与统计手册》第四版标准)的门诊患者。本文报告了该试验(于1999年10月至2004年9月进行)的12个月随访结果。盲法评估者对CBSST技能掌握情况、功能、精神病性和抑郁症状以及认知洞察力(信念灵活性)进行了评估。
治疗结束时,CBSST组患者相比TAU组患者在技能习得及社区生活技能的自我报告表现上有显著提高,这种差异在12个月随访时得以维持(p≤0.05)。CBSST组的参与者在治疗结束时相对于TAU组也表现出显著更高的认知洞察力,但这种改善在随访时未得以维持。在任何评估点,治疗组对症状的影响均不显著;然而,在这个稳定的门诊样本中,症状并非主要治疗目标。
患有非常慢性精神分裂症的老年人能够通过CBSST学习并维持新技能,且在治疗结束1年后自我报告的功能有所改善。可能需要更长时间的治疗和/或强化治疗来维持认知洞察力方面的收获。