Reynolds Charles F, Jeste Dilip V, Sachdev Perminder S, Blazer Dan G
University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
World Psychiatry. 2022 Oct;21(3):336-363. doi: 10.1002/wps.20996.
The world's population is aging, bringing about an ever-greater burden of mental disorders in older adults. Given multimorbidities, the mental health care of these people and their family caregivers is labor-intensive. At the same time, ageism is a big problem for older people, with and without mental disorders. Positive elements of aging, such as resilience, wisdom and prosocial behaviors, need to be highlighted and promoted, both to combat stigma and to help protect and improve mental health in older adults. The positive psychiatry of aging is not an oxymoron, but a scientific construct strongly informed by research evidence. We champion a broader concept of geriatric psychiatry - one that encompasses health as well as illness. In the present paper, we address these issues in the context of four disorders that are the greatest source of years lived with disability: neurocognitive disorders, major depression, schizophrenia, and substance use disorders. We emphasize the need for implementation of multidisciplinary team care, with comprehensive assessment, clinical management, intensive outreach, and coordination of mental, physical and social health services. We also underscore the need for further research into moderators and mediators of treatment response variability. Because optimal care of older adults with mental disorders is both patient-focused and family-centered, we call for further research into enhancing the well-being of family caregivers. To optimize both the safety and efficacy of pharmacotherapy, further attention to metabolic, cardiovascular and neurological tolerability is much needed, together with further development and testing of medications that reduce the risk for suicide. At the same time, we also address positive aging and normal cognitive aging, both as an antidote to ageism and as a catalyst for change in the way we think about aging per se and late-life mental disorders more specifically. It is in this context that we provide directions for future clinical care and research.
世界人口正在老龄化,给老年人带来了日益沉重的精神障碍负担。鉴于存在多种疾病,对这些患者及其家庭护理人员的精神卫生保健工作需要耗费大量人力。与此同时,年龄歧视对老年人来说是个大问题,无论他们是否患有精神障碍。需要强调和弘扬衰老的积极因素,如恢复力、智慧和亲社会行为,这既能消除污名化,又有助于保护和改善老年人的心理健康。老年积极精神病学并非自相矛盾,而是一个有充分研究证据支撑的科学概念。我们倡导更广泛的老年精神病学概念——一个涵盖健康与疾病的概念。在本文中,我们将在四种导致失能生存年限的主要疾病背景下探讨这些问题,这四种疾病分别是神经认知障碍、重度抑郁症、精神分裂症和物质使用障碍。我们强调需要实施多学科团队护理,包括全面评估、临床管理、强化外展服务以及精神、身体和社会健康服务的协调。我们还强调需要进一步研究治疗反应变异性的调节因素和中介因素。由于对患有精神障碍的老年人进行最佳护理既要以患者为中心,也要以家庭为中心,我们呼吁进一步研究如何提高家庭护理人员的幸福感。为了优化药物治疗的安全性和有效性,迫切需要进一步关注药物的代谢、心血管和神经耐受性,同时还要进一步研发和测试降低自杀风险的药物。与此同时,我们也探讨积极老龄化和正常认知老化,这既是消除年龄歧视的解药,也是改变我们对衰老本身以及更具体地说对晚年精神障碍的看法的催化剂。正是在这一背景下,我们为未来的临床护理和研究提供指导方向。