Markham S M, Dubin N H, Rock J A
Department of Gynecology and Obstetrics, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Am J Obstet Gynecol. 1991 Dec;165(6 Pt 1):1821-9. doi: 10.1016/0002-9378(91)90039-t.
Menstrual cycle variations in platelet aggregation and thromboxane production in association with sex steroids have been reported. External stimuli such as decompression sickness have been associated with clotting activity changes, specifically, increased platelet aggregation. Differences in response of platelets from women and men, when subjected to such a stress, have been observed. This study evaluated the ability of washed platelets from women in the proliferative and secretory phases of the menstrual cycle to aggregate in response to arachidonic acid and the aggregation difference between washed platelets from women and men in response to decompression stress and arachidonic acid. Additionally, platelet thromboxane production differences between the assessed platelet populations were compared. Our results indicate no difference in platelet aggregability between phases of the menstrual cycle. A significant aggregation difference between platelets from women and men was noted. Platelets from women were more sensitive to arachidonic acid aggregation. These differences were not affected by decompression stress. No difference in thromboxane B2 production was noted between the platelet populations evaluated.
据报道，血小板聚集和血栓素生成的月经周期变化与性类固醇有关。诸如减压病等外部刺激与凝血活性变化有关，具体而言，是血小板聚集增加。在受到这种应激时，已观察到女性和男性血小板反应的差异。本研究评估了处于月经周期增殖期和分泌期的女性洗涤血小板对花生四烯酸的聚集能力，以及女性和男性洗涤血小板在应对减压应激和花生四烯酸时的聚集差异。此外，还比较了所评估血小板群体之间的血小板血栓素生成差异。我们的结果表明，月经周期各阶段之间血小板聚集性无差异。注意到女性和男性血小板之间存在显著的聚集差异。女性血小板对花生四烯酸聚集更敏感。这些差异不受减压应激影响。在所评估的血小板群体之间，未观察到血栓素B2生成的差异。
