Rees M C, Demers L M, Anderson A B, Turnbull A C
Br J Obstet Gynaecol. 1984 Jul;91(7):667-72. doi: 10.1111/j.1471-0528.1984.tb04828.x.
Platelets were isolated from menstrual and peripheral venous blood samples taken from nine women during the first 2 days of menstruation. The washed platelets were tested for their ability to aggregate in response to arachidonic acid, ADP, and collagen, and to metabolize arachidonic acid. Menstrual platelets differed from venous platelets in (1) failing to aggregate when challenged with aggregatory stimuli and (2) producing no appreciable cyclo-oxygenase products from arachidonic acid as reflected in thromboxane B2 release. However, incubation of peripheral venous platelets with menstrual serum obtained from the same patients induced aggregation. The responses of menstrual and peripheral venous platelets were the same irrespective of the patients' total menstrual blood loss. Uterine venous platelets collected during menstruation from two patients at hysterectomy aggregated normally and produced thromboxane B2.
从9名女性月经周期第1至2天采集的月经血和外周静脉血样本中分离出血小板。对洗涤后的血小板进行检测，以评估其对花生四烯酸、二磷酸腺苷（ADP）和胶原的聚集能力，以及代谢花生四烯酸的能力。月经血小板与静脉血小板的不同之处在于：（1）受到聚集刺激时无法聚集；（2）如血栓素B2释放所示，花生四烯酸不会产生明显的环氧化酶产物。然而，用同一患者的月经血清孵育外周静脉血小板会诱导聚集。无论患者的月经失血总量如何，月经血小板和外周静脉血小板的反应都是相同的。在子宫切除术中从两名患者身上采集的子宫静脉血小板正常聚集并产生血栓素B2。
