12项前瞻性研究的汇总分析中的酒精摄入量与肾细胞癌

Alcohol intake and renal cell cancer in a pooled analysis of 12 prospective studies.

作者信息

Lee Jung Eun, Hunter David J, Spiegelman Donna, Adami Hans-Olov, Albanes Demetrius, Bernstein Leslie, van den Brandt Piet A, Buring Julie E, Cho Eunyoung, Folsom Aaron R, Freudenheim Jo L, Giovannucci Edward, Graham Saxon, Horn-Ross Pamela L, Leitzmann Michael F, McCullough Marjorie L, Miller Anthony B, Parker Alexander S, Rodriguez Carmen, Rohan Thomas E, Schatzkin Arthur, Schouten Leo J, Virtanen Mikko, Willett Walter C, Wolk Alicja, Zhang Shumin M, Smith-Warner Stephanie A

机构信息

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

出版信息

J Natl Cancer Inst. 2007 May 16;99(10):801-10. doi: 10.1093/jnci/djk181.

DOI:10.1093/jnci/djk181

PMID:17505075

Abstract

BACKGROUND

The association between alcohol intake and risk of renal cell cancer has been inconsistent in case-control studies. An inverse association between alcohol intake and risk of renal cell cancer has been suggested in a few prospective studies, but each of these studies included a small number of cases.

METHODS

We performed a pooled analysis of 12 prospective studies that included 530,469 women and 229,575 men with maximum follow-up times of 7-20 years. All participants had completed a validated food-frequency questionnaire at baseline. Using the primary data from each study, the study-specific relative risks (RRs) for renal cell cancer were calculated using Cox proportional hazards models and then pooled using a random-effects model. All statistical tests were two-sided.

RESULTS

A total of 1430 (711 women and 719 men) cases of incident renal cell cancer were identified. The study-standardized incidence rates of renal cell cancer were 23 per 100,000 person-years among nondrinkers and 15 per 100,000 person-years among those who drank 15 g/day or more of alcohol. Compared with nondrinking, alcohol consumption (> or = 15 g/day, equivalent to slightly more than one alcoholic drink per day) was associated with a decreased risk of renal cell cancer (pooled multivariable RR = 0.72, 95% confidence interval = 0.60 to 0.86; P(trend)<.001); statistically significant inverse trends with increasing intake were seen in both women and men. No difference by sex was observed (P(heterogeneity) = .89). Associations between alcohol intake and renal cell cancer were not statistically different across alcoholic beverage type (beer versus wine versus liquor) (P = .40).

CONCLUSION

Moderate alcohol consumption was associated with a lower risk of renal cell cancer among both women and men in this pooled analysis.

摘要

背景

在病例对照研究中，饮酒与肾细胞癌风险之间的关联并不一致。一些前瞻性研究提示饮酒与肾细胞癌风险呈负相关，但这些研究中的每一项纳入的病例数都较少。

方法

我们对12项前瞻性研究进行了汇总分析，这些研究包括530469名女性和229575名男性，最长随访时间为7至20年。所有参与者在基线时都完成了一份经过验证的食物频率问卷。利用每项研究的原始数据，使用Cox比例风险模型计算肾细胞癌的研究特异性相对风险（RRs），然后使用随机效应模型进行汇总。所有统计检验均为双侧检验。

结果

共识别出1430例（711名女性和719名男性）新发肾细胞癌病例。肾细胞癌的研究标准化发病率在不饮酒者中为每10万人年23例，在每天饮酒15克或更多的人群中为每10万人年15例。与不饮酒相比，饮酒（≥15克/天，相当于每天略多于一杯酒精饮料）与肾细胞癌风险降低相关（汇总多变量RR = 0.72，95%置信区间 = 0.60至0.86；P趋势<.001）；在女性和男性中均观察到随着饮酒量增加有统计学意义的负向趋势。未观察到性别差异（P异质性 =.89）。饮酒与肾细胞癌之间的关联在不同酒精饮料类型（啤酒与葡萄酒与烈酒）之间无统计学差异（P =.40）。