Xu Xin, Zhu Yi, Zheng Xiangyi, Xie Liping
Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Oncotarget. 2015 May 30;6(15):13347-58. doi: 10.18632/oncotarget.3749.
Despite plenty of evidence supports an inverse association between alcohol drinking and risk of renal cell carcinoma (RCC), sex-specific and beverage-specific dose-response relationships have not been well established. We examined this association by performing a systematic review and meta-analysis of prospective studies. Studies were identified by comprehensively searching PubMed and EMBASE databases through February 21, 2015. Categorical and dose-response meta-analyses were conducted to identify the effects of alcohol on RCC. A total of eight publications (including seven cohort studies and one pooled analysis of 12 cohort studies) were eligible for this meta-analysis. Dose-response analysis showed that each 5 g/day increment of alcohol intake corresponded to a 5% decrease in risk of RCC for males and 9% for females. Alcohol intakes from wine, beer, and liquor were each associated with a reduced risk of RCC. When these associations were examined separately by gender, statistically significant inverse associations were restricted to alcohol from wine among females (RR = 0.82, 95% CI 0.73-0.91) and to alcohol from beer and from liquor among males (RR = 0.87, 95% CI 0.83-0.91 and RR = 0.95, 95% CI 0.92-0.99, respectively). In conclusion, there exist gender-specific and beverage-specific differences in the association between alcohol intake and RCC risk.
尽管有大量证据支持饮酒与肾细胞癌（RCC）风险之间存在负相关，但性别特异性和饮料特异性的剂量反应关系尚未完全确立。我们通过对前瞻性研究进行系统评价和荟萃分析来研究这种关联。通过全面检索截至2015年2月21日的PubMed和EMBASE数据库来识别研究。进行分类和剂量反应荟萃分析以确定酒精对肾细胞癌的影响。共有八篇出版物（包括七项队列研究和一项对12项队列研究的汇总分析）符合这项荟萃分析的条件。剂量反应分析表明，男性酒精摄入量每增加5克/天，肾细胞癌风险降低5%，女性降低9%。葡萄酒、啤酒和烈酒的酒精摄入量均与肾细胞癌风险降低相关。当按性别分别检查这些关联时，统计学上显著的负相关仅限于女性饮用葡萄酒（RR = 0.82，95% CI 0.73 - 0.91）以及男性饮用啤酒和烈酒（RR分别为0.87，95% CI 0.83 - 0.91和RR = 0.95，95% CI 0.92 - 0.99）。总之，酒精摄入量与肾细胞癌风险之间的关联存在性别特异性和饮料特异性差异。
