Buerk Donald G
Departments of Physiology and Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
Antioxid Redox Signal. 2007 Jul;9(7):829-43. doi: 10.1089/ars.2007.1551.
The role of nitric oxide (NO) as a highly diffusible free radical gaseous vasodilator is intrinsically linked to the control of blood flow and oxygen (O(2)) delivery to tissue. NO also is involved in regulating mitochondrial O(2) metabolism, growth of new blood vessels, and blood oxygenation through control of respiratory ventilation. Hemoglobin and myoglobin may help to conserve NO for subsequent release of a NO-related vasoactive species under hypoxic conditions. NO has a major role in regulating microvascular O(2), and dysfunctional NO signaling is associated with the pathogenesis of metabolic and cardiovascular diseases.
一氧化氮（NO）作为一种高度可扩散的自由基气体血管舒张剂，其作用与血流控制以及氧气（O₂）向组织的输送有着内在联系。NO还参与调节线粒体的O₂代谢、新血管的生长以及通过控制呼吸通气来实现血液氧合。血红蛋白和肌红蛋白可能有助于保存NO，以便在低氧条件下随后释放与NO相关的血管活性物质。NO在调节微血管O₂方面起主要作用，而功能失调的NO信号传导与代谢和心血管疾病的发病机制相关。
