Gennari C, Galli M, Montagnani M
J Clin Pathol. 1976 Jan;29(1):69-72. doi: 10.1136/jcp.29.1.69.
The 24-hour urinary excretion of cyclic 3',5'-adenosine monophosphate (cAMP) was measured by a protein-binding assay in 55 healthy volunteers (aged 20-35 yr) and in 30 hospitalized elderly subjects (aged 70-93 yr). In the older subjects the mean 24-hour cAMP excretion was significantly lower; the correlation between cAMP excretion and age demonstrated a progressive decrease from the age of 70 to the tenth decade. Many different factors could account for the reduced urinary cAMP excretion in elderly subjects: a decline in the reactivity of the adenyl cyclase-cAMP system related to physiological ageing; reduced physical activity; a reduction in the glomerular filtration rate or decreased production of cAMP by tubular cells in the senile kidney.
通过蛋白结合分析法测定了55名健康志愿者(年龄20 - 35岁)和30名住院老年受试者(年龄70 - 93岁)24小时尿中环磷酸腺苷(cAMP)的排泄量。在老年受试者中,24小时cAMP平均排泄量显著降低;cAMP排泄量与年龄之间的相关性表明,从70岁到九十多岁呈逐渐下降趋势。许多不同因素可解释老年受试者尿中cAMP排泄减少的现象:与生理衰老相关的腺苷酸环化酶 - cAMP系统反应性下降;体力活动减少;肾小球滤过率降低或老年肾脏中肾小管细胞产生cAMP减少。