Hinds Pamela S, Burghen Elizabeth A, Zhou Yinmei, Zhang Lijun, West Nancy, Bashore Lisa, Pui Ching-Hon
Division of Nursing Research, St Jude Children's Research Hospital, Memphis, TN 38105, USA.
Cancer Nurs. 2007 May-Jun;30(3):169-77. doi: 10.1097/01.NCC.0000270700.11425.4d.
When health-related quality of life instruments developed for and validated in 1 respondent group are completed by a different respondent group, findings could be invalid. The purpose of this study was to summarize the instrument outcomes when a widely used health-related quality of life instrument (the Health Utilities Index 3 [HUI3]) created from a population-based strategy was completed by pediatric oncology nurses for their patients during cancer treatment. Fifty-four nurses completed the HUI3 a total of 261 times at 1 to 3 sequential data points (106, 94, and 61, respectively) for pediatric patients who were enrolled on a frontline therapeutic clinical trial for acute lymphoblastic leukemia. Data were collected at 2 children's hospitals. HUI3 scores could not be calculated for 52% to 61% of the nurse reports at each of the 3 data points because of nurses' use of the "do not know" response option. Missing data of this proportion indicate that the nurse serving as a proxy rater independent of directly soliciting responses from the patient will not be able to rate certain attributes of the HUI3 more than half of the time despite having ongoing familiarity with the patient. Because of this, use of the HUI3 by nurse proxies for patients with pediatric acute lymphoblastic leukemia is not recommended.
当为一个应答群体开发并验证的健康相关生活质量工具由不同的应答群体完成时，研究结果可能无效。本研究的目的是总结一种广泛使用的健康相关生活质量工具（健康效用指数3 [HUI3]）的测量结果，该工具是基于人群策略创建的，由儿科肿瘤护士在癌症治疗期间为其患者填写。54名护士在1至3个连续数据点（分别为106次、94次和61次）总共完成了261次HUI3的填写，这些数据点针对的是参加急性淋巴细胞白血病一线治疗临床试验的儿科患者。数据在两家儿童医院收集。由于护士使用了“不知道”的回答选项，在3个数据点中的每一个数据点，52%至61%的护士报告无法计算HUI3得分。如此比例的缺失数据表明，尽管护士持续了解患者情况，但作为代理评分者，在超过一半的时间里，护士无法对HUI3的某些属性进行评分。因此，不建议儿科急性淋巴细胞白血病患者的护士代理使用HUI3。
