Benedek Birgit, Gjoncaj Noela, Saukel Johannes, Kopp Brigitte
Department of Pharmacognosy, University of Vienna, Vienna.
Chem Biodivers. 2007 May;4(5):849-57. doi: 10.1002/cbdv.200790072.
Achillea millefolium L. s.l. is a cytogenetically, morphologically, and chemically polymorphic aggregate. Besides the sesquiterpenes that possess chemotaxonomic relevance and mediate the antiphlogistic activity, the plant contains phenolic compounds such as dicaffeoylquinic acids and flavonoids causing choleretic and spasmolytic effects. To evaluate their contribution to the chemotaxonomy of European taxa of the A. millefolium group, we developed a SPE-HPLC/UV method that allows quantification of the phenolic constituents in the different taxa. The investigated species displayed differences in the quantitative and qualitative composition of phenolic acids and flavonoids. Hence, they seem to be of chemotaxonomic significance, especially for the distinction of the diploid taxa. Combining the obtained results with the data of the sesquiterpene analyses gives a comprehensive insight into the distribution of those pharmacologically relevant plant constituents in the A. millefolium group.
广义的蓍草（Achillea millefolium L.）是一个在细胞遗传学、形态学和化学方面具有多态性的类群。除了具有化学分类学相关性并介导抗炎活性的倍半萜类化合物外，该植物还含有酚类化合物，如二咖啡酰奎宁酸和黄酮类化合物，具有利胆和解痉作用。为了评估它们对蓍草属欧洲类群化学分类学的贡献，我们开发了一种固相萃取-高效液相色谱/紫外检测方法，该方法可对不同类群中的酚类成分进行定量分析。所研究的物种在酚酸和黄酮类化合物的定量和定性组成上存在差异。因此，它们似乎具有化学分类学意义，特别是对于二倍体类群的区分。将所得结果与倍半萜分析数据相结合，能全面了解这些具有药理活性的植物成分在蓍草属类群中的分布情况。
