Department of Pharmaceutical Chemistry and Pharmacognosy, Kaunas University of Medicine, Kaunas, Lithuania.
Medicina (Kaunas). 2008;44(10):775-81.
Achillea millefolium L. sensu lato (yarrow) is the best-known species of the genus Achillea due to numerous medicinal applications both in folk and conventional medicine. Phenolic compounds such as flavonoids and phenol carbonic acids are present in yarrow and constitute one of the most important groups of pharmacologically active substances. In the present study, yarrow flowers gathered from native populations in different locations of Lithuania were analyzed for phenolic compound composition. High-performance liquid chromatography (HPLC) was used for chemical analyses. Eight phenolic compounds--chlorogenic acid and flavonoids, namely vicenin-2, luteolin-3',7-di-O-glucoside, luteolin-7-O-glucoside, rutin, apigenin-7-O-glucoside, luteolin, and apigenin--were identified in the extracts from yarrow flowers. Considerable variation in accumulation of phenolic compounds among the flowers from different locations was observed. The samples were divided into two main groups based on chemical composition: the first group was characterized by lower than the mean total amount of the identified phenolics; the second was formed from samples accumulating higher concentrations of investigated secondary metabolites. The total amount of the identified phenolics in yarrow flowers from different populations varied from 13.290 to 27.947 mg/g.
皱叶酸模（Rumex crispus）是酸模属中最著名的物种之一，由于其在民间医学和传统医学中具有众多药用应用而广为人知。类黄酮和酚羧酸等酚类化合物存在于皱叶酸模中，构成了最重要的一类具有药理活性的物质之一。在本研究中，分析了来自立陶宛不同地点的本地种群皱叶酸模花中的酚类化合物组成。采用高效液相色谱法（HPLC）进行化学分析。从皱叶酸模花提取物中鉴定出 8 种酚类化合物——绿原酸和类黄酮，即 vicenin-2、木犀草素-3'，7-二-O-葡萄糖苷、木犀草素-7-O-葡萄糖苷、芦丁、芹菜素-7-O-葡萄糖苷、木犀草素和芹菜素。观察到不同地点的花中酚类化合物的积累存在相当大的差异。根据化学成分将样品分为两组：第一组的特征是鉴定出的酚类化合物总量低于平均值；第二组由积累了更高浓度研究的次生代谢物的样品组成。不同种群皱叶酸模花中的鉴定出的酚类化合物总量从 13.290 到 27.947mg/g 不等。
