Akturk M, Altinova A E, Mert I, Buyukkagnici U, Sargin A, Arslan M, Danisman N
Department of Endocrinology and Metabolism, Faculty of Medicine, Gazi University, Ankara, Turkey.
J Endocrinol Invest. 2008 Jul;31(7):610-3. doi: 10.1007/BF03345611.
Our aim is to investigate visfatin concentration and its relationship to glycated hemoglobin (HbA1c), insulin resistance, lipid parameters, and neonatal birth weight in women with gestational diabetes mellitus (GDM). In our study group, there were 47 women with GDM and 31 women with normal glucose tolerance (NGT) between 33-39 weeks of gestation. Plasma visfatin levels were significantly decreased in pregnant women with GDM compared to those with NGT (p=0.001). Homeostasis model assessment-insulin resistance (HOMA-IR) levels were higher in the GDM group than in the NGT group (p=0.006). In all subjects, plasma visfatin levels were negatively correlated with HOMA-IR, post-prandial blood glucose, triglycerides, and VLDL cholesterol (p<0.05). We did not observe any statistically significant correlation between the plasma visfatin levels and the selected parameters in the GDM group, but in the NGT group plasma visfatin levels were negatively correlated with HOMA-IR (r=-0.36, p=0.04). There was no correlation between visfatin concentrations and fetal birth weight in either group (p>0.05). By regression analysis, having GDM was found to be the only significant determinant (t=3.5, p=0.001) of visfatin concentration (R=0.39, r2=0.15). We conclude that women with GDM have significantly decreased visfatin concentrations in the third trimester. Future studies are required to establish the exact role of visfatin in the pathogenesis of GDM.
我们的目的是研究妊娠糖尿病（GDM）女性体内内脂素浓度及其与糖化血红蛋白（HbA1c）、胰岛素抵抗、血脂参数和新生儿出生体重的关系。在我们的研究组中，有47例妊娠33 - 39周的GDM女性和31例糖耐量正常（NGT）的女性。与NGT女性相比，GDM孕妇的血浆内脂素水平显著降低（p = 0.001）。GDM组的稳态模型评估-胰岛素抵抗（HOMA-IR）水平高于NGT组（p = 0.006）。在所有受试者中，血浆内脂素水平与HOMA-IR、餐后血糖、甘油三酯和极低密度脂蛋白胆固醇呈负相关（p < 0.05）。我们未观察到GDM组血浆内脂素水平与所选参数之间存在任何统计学显著相关性，但在NGT组中，血浆内脂素水平与HOMA-IR呈负相关（r = -0.36，p = 0.04）。两组中内脂素浓度与胎儿出生体重均无相关性（p > 0.05）。通过回归分析，发现患有GDM是内脂素浓度的唯一显著决定因素（t = 3.5，p = 0.001）（R = 0.39，r2 = 0.15）。我们得出结论，GDM女性在妊娠晚期内脂素浓度显著降低。需要进一步的研究来确定内脂素在GDM发病机制中的确切作用。
