Davies Owen R, Lewis Andrew L, Whitaker Martin J, Tai Hongyun, Shakesheff Kevin M, Howdle Steven M
Critical Pharmaceuticals Ltd BioCity Pennyfoot St., Nottingham, NG1 1GF, United Kingdom.
Adv Drug Deliv Rev. 2008 Feb 14;60(3):373-87. doi: 10.1016/j.addr.2006.12.001. Epub 2007 Oct 5.
Supercritical CO(2) has the potential to be an excellent environment within which controlled release polymers and dry composites may be formed. The low temperature and dry conditions within the fluid offer obvious advantages in the processing of water, solvent or heat labile molecules. The low viscosity and high diffusivity of scCO(2) offer the possibility of novel processing routes for polymer drug composites, but there are still technical challenges to overcome. Moreover, the low solubility of most drug molecules in scCO(2) presents both challenges and advantages. This review explores the current methods that use high pressure and scCO(2) for the production of drug delivery systems and the more specialized application of the fluid in the formation of highly porous tissue engineering scaffolds.
超临界二氧化碳有潜力成为一个优良的环境，在此环境中可形成控释聚合物和干复合材料。该流体内部的低温和干燥条件在处理对水、溶剂或热敏感的分子时具有明显优势。超临界二氧化碳的低粘度和高扩散性为聚合物药物复合材料提供了新的加工路线，但仍有技术挑战有待克服。此外，大多数药物分子在超临界二氧化碳中的低溶解度既带来了挑战，也有优势。本综述探讨了目前利用高压和超临界二氧化碳生产药物递送系统的方法，以及该流体在形成高度多孔的组织工程支架方面的更专业应用。
