Washio Masakazu, Mori Mitsuru, Khan Mmh, Sakauchi Fumio, Watanabe Yoshiyuki, Ozasa Kotaro, Hayashi Kyohei, Miki Tsuneharu, Nakao Masahiro, Mikami Kazuya, Ito Yoshinori, Kubo Tatsuhiko, Wakai Kenji, Tamakoshi Akiko
Department of Public Health, Sapporo Medical University School of Medicine, Sapporo, Japan.
Int J Urol. 2007 May;14(5):393-7. doi: 10.1111/j.1442-2042.2007.01744.x.
Diabetes mellitus (DM) is reported as being a risk factor associated with kidney cancer in Western countries. The incidence of both kidney cancer and DM is lower in Japan than the other developed countries, albeit on the rise.
We evaluated the risk factors for kidney cancer mortality using the database of the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC) study. The analytic cohort included 46 462 males and 64 326 females aged 40-79 years old. The Cox proportional hazards model was used to determine age- and sex-adjusted relative risk and its 95% confidence intervals.
DM showed an increased, age- and sex-adjusted hazard ratio for kidney cancer mortality, but it failed to achieve statistical significance after controlling for other factors.
The present study showed that DM increased the risk of kidney cancer death among the Japanese population. However, further studies may be needed to confirm the findings in the present study because DM failed to remain as a significant risk factor after controlling for other factors because of the small number of kidney cancer deaths in the present study.
在西方国家，糖尿病（DM）被报道为与肾癌相关的一个风险因素。在日本，尽管肾癌和糖尿病的发病率都在上升，但仍低于其他发达国家。
我们使用日本癌症风险评估协作队列研究（JACC）的数据库评估了肾癌死亡率的风险因素。分析队列包括46462名年龄在40 - 79岁之间的男性和64326名女性。采用Cox比例风险模型来确定年龄和性别调整后的相对风险及其95%置信区间。
糖尿病显示出年龄和性别调整后的肾癌死亡率风险增加，但在控制其他因素后未达到统计学显著性。
本研究表明，糖尿病增加了日本人群中肾癌死亡的风险。然而，由于本研究中肾癌死亡人数较少，糖尿病在控制其他因素后未能作为一个显著的风险因素保留下来，可能需要进一步研究来证实本研究的结果。
