Escher Geneviève, Mohaupt Markus
University Hospital of Berne, Division of Nephrology and Hypertension, 3010 Berne, Switzerland.
Mol Aspects Med. 2007 Apr;28(2):245-54. doi: 10.1016/j.mam.2007.03.002. Epub 2007 Apr 11.
Preeclampsia is a hypertensive disorder unique to pregnancy and remains the leading cause of maternal and fetal morbidity and mortality. Despite active research, the etiology of this disease remains still an enigma. There is increasing evidence that a combination of several factors is responsible for the development of preeclampsia. In this review, we discuss the role of aldosterone in the regulation of body fluid in pregnancy and preeclampsia. Aldosterone is produced by the enzyme aldosterone synthase and competes with cortisol and progesterone for the mineralocorticoid receptor, thus affecting sodium reabsorption and maternal volume expansion. Aldosterone seems to play a pivotal role in controlling blood pressure during pregnancy and to contribute to the well-being of the mother-to-be. Novel findings in understanding the underlying causes of preeclampsia provide a rationale for future novel prophylactic and therapeutic interventions in the treatment of this pregnancy-associated disease.
子痫前期是一种妊娠特有的高血压疾病，仍是孕产妇和胎儿发病及死亡的主要原因。尽管进行了积极的研究，但这种疾病的病因仍然是个谜。越来越多的证据表明，多种因素共同作用导致了子痫前期的发生。在这篇综述中，我们讨论醛固酮在妊娠和子痫前期体液调节中的作用。醛固酮由醛固酮合酶产生，与皮质醇和孕酮竞争盐皮质激素受体，从而影响钠重吸收和母体血容量增加。醛固酮似乎在孕期控制血压方面起着关键作用，并有助于准妈妈的健康。在理解子痫前期潜在病因方面的新发现为未来治疗这种妊娠相关疾病的新型预防和治疗干预提供了理论依据。
