Anu Research Centre, Department of Obstetrics & Gynaecology, University College Cork, Cork University Maternity Hospital, Wilton, Cork, Ireland.
Placenta. 2011 Jun;32(6):413-9. doi: 10.1016/j.placenta.2011.03.010. Epub 2011 Apr 17.
Preeclampsia remains a leading cause of maternal and fetal morbidity and mortality and has an unknown etiology. The limited progress made regarding new treatments to reduce the incidence and severity of preeclampsia has been attributed to the difficulties faced in the development of suitable animal models for the mechanistic research of this disease. In addition, animal models need hypotheses on which to be based and the slow development of testable hypotheses has also contributed to this poor progress. The past decade has seen significant advances in our understanding of preeclampsia and the development of viable reproducible animal models has contributed significantly to these advances. Although many of these models have features of preeclampsia, they are still poor overall models of the human disease and limited due to lack of reproducibility and because they do not include the complete spectrum of pathophysiological changes associated with preeclampsia. This review aims to provide a succinct and comprehensive assessment of current animal models of preeclampsia, their uses and limitations with particular attention paid to the best validated and most comprehensive models, in addition to those models which have been utilized to investigate potential therapeutic interventions for the treatment or prevention of preeclampsia.
子痫前期仍然是孕产妇和胎儿发病率和死亡率的主要原因，其病因不明。在减少子痫前期发病率和严重程度的新治疗方法方面取得的进展有限，这归因于在这种疾病的机制研究中开发合适的动物模型所面临的困难。此外，动物模型需要基于假设，而可测试假设的缓慢发展也促成了这一进展不佳。过去十年，我们对子痫前期的认识有了显著的提高，可行的可复制的动物模型的发展对这些进展做出了重大贡献。尽管这些模型中的许多都具有子痫前期的特征，但它们仍然不是人类疾病的良好整体模型，由于缺乏可重复性，并且由于它们不包括与子痫前期相关的所有病理生理变化，因此受到限制。本综述旨在对目前子痫前期的动物模型进行简洁而全面的评估，特别关注经过最佳验证和最全面的模型，以及那些用于研究潜在治疗干预措施以治疗或预防子痫前期的模型。
