对小鼠肝炎病毒具有遗传抗性的巨噬细胞在体外转化为易感巨噬细胞。
Macrophages genetically resistant to mouse hepatitis virus converted in vitro to susceptible macrophages.
作者信息
Weiser W, Bang F B
出版信息
J Exp Med. 1976 Mar 1;143(3):690-5. doi: 10.1084/jem.143.3.690.
Abstract
Genetic resistance to mouse hepatitis, which resides largely in the macrophages of resistant C3H mice, may be altered by exposing the cells in vitro to fluid from allogeneic mixed lymphocytes. A 1,000-fold increase in susceptibility was produced in these genetically resistant cells by exposure to this fluid. This presumed lymphokine was effective without producing any change in host adaption of the virus.
摘要
对小鼠肝炎的遗传抗性主要存在于抗性C3H小鼠的巨噬细胞中，通过在体外将这些细胞暴露于同种异体混合淋巴细胞的培养液中，这种抗性可能会发生改变。通过暴露于这种培养液，这些具有遗传抗性的细胞的易感性增加了1000倍。这种推测的淋巴因子是有效的，且不会对病毒在宿主体内的适应性产生任何改变。
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