Juárez-Cedillo Teresa, Vallejo Maite, Fragoso José Manuel, Hernández-Hernández Dulce Maria, Rodríguez-Pérez José Manuel, Sánchez-García Sergio, del Carmen García-Peña María, García-Carrancá Alejandro, Mohar-Betancourt Alejandro, Granados Julio, Vargas-Alarcón Gilberto
Epidemiological Research and Health Services Unit, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Eur J Cancer. 2007 Jul;43(10):1590-5. doi: 10.1016/j.ejca.2007.03.025. Epub 2007 May 18.
The aim of the study was to evaluate the association of two CYP1A1 polymorphisms (Msp1 and exon 7) with cervical cancer in Mexican women considering their smoking habit. The polymorphisms were determined in 310 individuals (155 with cervical cancer and 155 healthy controls). Women with MspI T/C or C/C showed increased risk of developing cervical cancer (3.7- and 8.3-fold increase, respectively) compared to women with T/T genotype. When smoking habit was considered, the risk for non-smokers with T/C and C/C genotypes was similar (5.2 and 4.1, respectively), whereas smoking women with C/C genotype showed a 19.4-fold increase of cervical cancer. Number of child births, number of sexual partners and marital status were strong risk factors for developing cervical cancer in women with T/T genotype; however, in women with T/C genotype, only the number of child births and sexual partners had a significant influence. These results suggest an important role of the CYP1A1 MspI polymorphism in the risk of developing cervical cancer.
本研究的目的是在考虑墨西哥女性吸烟习惯的情况下，评估两种细胞色素P450 1A1（CYP1A1）基因多态性（Msp1和外显子7）与宫颈癌的关联。在310名个体（155例宫颈癌患者和155例健康对照）中测定了这些多态性。与T/T基因型的女性相比，MspI T/C或C/C基因型的女性患宫颈癌的风险增加（分别增加3.7倍和8.3倍）。考虑吸烟习惯时，T/C和C/C基因型的非吸烟女性风险相似（分别为5.2和4.1），而C/C基因型的吸烟女性患宫颈癌的风险增加19.4倍。对于T/T基因型的女性，生育次数、性伴侣数量和婚姻状况是患宫颈癌的强烈风险因素；然而，对于T/C基因型的女性，只有生育次数和性伴侣数量有显著影响。这些结果表明CYP1A1 MspI基因多态性在宫颈癌发生风险中起重要作用。
