一条漫长而曲折的道路：疟原虫子孢子在哺乳动物宿主中的旅程。
A long and winding road: the Plasmodium sporozoite's journey in the mammalian host.
作者信息
Sinnis Photini, Coppi Alida
机构信息
Department of Medical Parasitology, New York University School of Medicine, 341 East 25th Street, New York, NY 10010, United States.
出版信息
Parasitol Int. 2007 Sep;56(3):171-8. doi: 10.1016/j.parint.2007.04.002. Epub 2007 Apr 24.
Abstract
The Plasmodium sporozoite, the infectious stage of the malaria parasite, makes a remarkable journey in its mammalian host. Here we review our current knowledge of the molecular and cellular basis of this journey, which begins in the skin and ends in the hepatocyte.
摘要
疟原虫的子孢子是疟原虫的感染阶段，它在其哺乳动物宿主中经历了一段非凡的旅程。在这里，我们回顾了我们目前对这段旅程的分子和细胞基础的认识，这段旅程始于皮肤，止于肝细胞。
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本文引用的文献
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Cell Microbiol. 2007 May;9(5):1215-22. doi: 10.1111/j.1462-5822.2006.00861.x. Epub 2007 Jan 9.
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Alternative invasion pathways for Plasmodium berghei sporozoites.伯氏疟原虫子孢子的替代入侵途径。
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Kupffer cells are obligatory for Plasmodium yoelii sporozoite infection of the liver.库普弗细胞对于约氏疟原虫子孢子感染肝脏是必不可少的。
Cell Microbiol. 2007 Feb;9(2):397-412. doi: 10.1111/j.1462-5822.2006.00798.x. Epub 2006 Aug 31.
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Expression of human CD81 differently affects host cell susceptibility to malaria sporozoites depending on the Plasmodium species.人类CD81的表达对宿主细胞对疟原虫子孢子的易感性影响各异，具体取决于疟原虫的种类。
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CelTOS, a novel malarial protein that mediates transmission to mosquito and vertebrate hosts.CelTOS是一种新型疟原虫蛋白，可介导疟原虫向蚊子和脊椎动物宿主的传播。
Mol Microbiol. 2006 Mar;59(5):1369-79. doi: 10.1111/j.1365-2958.2005.05024.x.
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Nat Med. 2006 Feb;12(2):220-4. doi: 10.1038/nm1350. Epub 2006 Jan 22.
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Two proteins with 6-cys motifs are required for malarial parasites to commit to infection of the hepatocyte.疟原虫感染肝细胞需要两种具有6个半胱氨酸基序的蛋白质。
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Quantitative dynamics of Plasmodium yoelii sporozoite transmission by infected anopheline mosquitoes.感染疟蚊传播约氏疟原虫子孢子的定量动力学
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