通过含有高浓度镁和钙的水延缓舒米亚白内障大鼠的白内障发展。

Delay of cataract development in the Shumiya cataract rat by water containing enhanced concentrations of magnesium and calcium.

作者信息

Nagai Noriaki, Ito Yoshimasa

机构信息

School of Pharmacy, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502, Japan.

出版信息

Curr Eye Res. 2007 May;32(5):439-45. doi: 10.1080/02713680701329339.

DOI:10.1080/02713680701329339

PMID:17514529

Abstract

We demonstrate a delaying effect of deep-sea drinking water (DDW) containing enhanced magnesium ion (Mg(2 +)) and calcium ion (Ca(2 +)) concentrations on cataract development in Shumiya cataract rats (SCRs). The lenses of SCRs administered DDW-200 (Mg(2 +), 200 mg/L, Ca(2 +); 71 mg/L) were less opaque than those in SCRs administered purified water (PW). In SCRs administered DDW-200, a decrease in Mg(2 +) content and an increase in Ca(2 +) content in the lenses was prevented in comparison with SCRs administered PW. Nitric oxide (NO) levels in the lenses of SCRs administered DDW-200 were lower than those in SCRs administered PW. In conclusion, the administration of DDW-200 to SCRs has a potent delaying effect on cataract development, possibly due to preventing an increase in NO levels in the lens.

摘要

我们证明了富含高浓度镁离子（Mg(2+)）和钙离子（Ca(2+)）的深海饮用水（DDW）对舒米亚白内障大鼠（SCR）白内障发展具有延缓作用。给予DDW - 200（Mg(2+)，200 mg/L，Ca(2+)；71 mg/L）的SCR晶状体的混浊程度低于给予纯净水（PW）的SCR。与给予PW的SCR相比，给予DDW - 200的SCR晶状体中Mg(2+)含量降低和Ca(2+)含量增加的情况得到了预防。给予DDW - 200的SCR晶状体中的一氧化氮（NO）水平低于给予PW的SCR。总之，给SCR给予DDW - 200对白内障发展具有显著的延缓作用，这可能是由于防止了晶状体中NO水平的升高。