Tang T, Walsh S R, Prytherch D R, Lees T, Varty K, Boyle J R
Regional Vascular Unit, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK.
Br J Surg. 2007 Jun;94(6):717-21. doi: 10.1002/bjs.5808.
Vascular Biochemistry and Haematology Outcome Models (VBHOM) adopted the approach of using a minimum data set to model outcome. This study aimed to test such a model on a cohort of patients undergoing open elective and non-elective abdominal aortic aneurysm (AAA) repair.
A binary logistic regression model of risk of in-hospital mortality was built from the 2002-2004 submission to the UK National Vascular Database (NVD) (2718 patients). The subset of NVD data items used comprised serum levels of urea, sodium and potassium, haemoglobin, white cell count, sex, age and mode of admission. The model was applied prospectively using Hosmer-Lemeshow methodology to a test data set from the Cambridge Vascular Unit.
The validation set contained 327 patients, of whom 208 had elective AAA repair and 119 had emergency repair of a ruptured AAA. Outcome following elective and non-elective AAA repair could be described accurately using the same model. The overall mean predicted risk of death was 14.13 per cent, and 48 deaths were predicted. The actual number of deaths was 53 (chi(2) = 8.40, 10 d.f., P = 0.590; no evidence of lack of fit). The model also demonstrated good discrimination (c-index = 0.852).
The VBHOM approach has the advantage of using simple, objective clinical data that are easy to collect routinely. The VBHOM data items potentially allow prediction of risk in an individual patient before aneurysm surgery.
血管生物化学与血液学结果模型(VBHOM)采用使用最小数据集来构建结果模型的方法。本研究旨在对一组接受开放性择期和非择期腹主动脉瘤(AAA)修复手术的患者测试这样一个模型。
基于2002 - 2004年提交给英国国家血管数据库(NVD)的数据(2718例患者)建立了院内死亡风险的二元逻辑回归模型。所使用的NVD数据项子集包括尿素、钠和钾的血清水平、血红蛋白、白细胞计数、性别、年龄和入院方式。该模型采用Hosmer - Lemeshow方法前瞻性地应用于剑桥血管科的一个测试数据集。
验证集包含327例患者,其中208例行择期AAA修复,119例行破裂AAA的急诊修复。使用同一模型能够准确描述择期和非择期AAA修复后的结果。总体平均预测死亡风险为14.13%,预测死亡48例。实际死亡人数为53例(χ² = 8.�0,10自由度,P = 0.590;无拟合不足的证据)。该模型还显示出良好的区分度(c指数 = 0.852)。
VBHOM方法的优点是使用简单、客观且易于常规收集的临床数据。VBHOM数据项有可能在动脉瘤手术前预测个体患者的风险。