日本人群中纤维母细胞生长因子20基因与帕金森病
Fibroblast growth factor 20 gene and Parkinson's disease in the Japanese population.
作者信息
Satake Wataru, Mizuta Ikuko, Suzuki Satoko, Nakabayashi Yuko, Ito Chiyomi, Watanabe Masahiko, Takeda Atsushi, Hasegawa Kazuko, Sakoda Saburo, Yamamoto Mitsutoshi, Hattori Nobutaka, Murata Miho, Toda Tatsushi
机构信息
Division of Clinical Genetics, Department of Medical Genetics, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan.
出版信息
Neuroreport. 2007 Jun 11;18(9):937-40. doi: 10.1097/WNR.0b013e328133265b.
A genetic association between the fibroblast growth factor 20 (FGF20) gene and Parkinson's disease has been found by the pedigree disequilibrium test. This association, however, was not replicated by a case-control association study. In order to clarify the association between the FGF20 gene and Parkinson's disease, we attempted to replicate this association by a case-control association study using a large number of Japanese samples (1388 patients and 1891 controls). rs1721100 exhibited a significant difference in allele C versus G (P=0.0089), and in genotype CC+CG versus GG (P=0.0053). Haplotype association analysis showed that haplotype 2 was the protective haplotype for Parkinson's disease (permutation-P=0.0075). These results suggest that the FGF20 gene is a susceptibility gene for Parkinson's disease in the Japanese population.
通过系谱不平衡检验发现了成纤维细胞生长因子20（FGF20）基因与帕金森病之间的遗传关联。然而，该关联在病例对照关联研究中未得到重复验证。为了阐明FGF20基因与帕金森病之间的关联，我们尝试通过使用大量日本样本（1388例患者和1891例对照）的病例对照关联研究来重复这一关联。rs1721100在等位基因C与G之间显示出显著差异（P = 0.0089），在基因型CC + CG与GG之间也有显著差异（P = 0.0053）。单倍型关联分析表明，单倍型2是帕金森病的保护性单倍型（置换P = 0.0075）。这些结果表明，FGF20基因是日本人群中帕金森病的一个易感基因。
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