Clarimon Jordi, Xiromerisiou Georgia, Eerola Johanna, Gourbali Vanesa, Hellström Olli, Dardiotis Euthimios, Peuralinna Terhi, Papadimitriou Alexandros, Hadjigeorgiou George M, Tienari Pentti J, Singleton Andrew B
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Building 35, Room 1A1000, Bethesda, MD 20892, USA.
BMC Neurol. 2005 Jun 20;5:11. doi: 10.1186/1471-2377-5-11.
Fibroblast growth factor 20 (FGF20) is a neurotrophic factor preferentially expressed in the substantia nigra of rat brain and could be involved in dopaminergic neurons survival. Recently, a strong genetic association has been found between FGF20 gene and the risk of suffering from Parkinson's disease (PD). Our aim was to replicate this association in two independent populations.
Allelic, genotypic, and haplotype frequencies of four biallelic polymorphisms were assessed in 151 sporadic PD cases and 186 controls from Greece, and 144 sporadic PD patients and 135 controls from Finland.
No association was found in any of the populations studied.
Taken together, these findings suggest that common genetic variants in FGF20 are not a risk factor for PD in, at least, some European populations.
成纤维细胞生长因子20(FGF20)是一种神经营养因子,在大鼠脑黑质中优先表达,可能参与多巴胺能神经元的存活。最近,已发现FGF20基因与患帕金森病(PD)的风险之间存在强烈的遗传关联。我们的目的是在两个独立人群中复制这种关联。
在来自希腊的151例散发性PD病例和186例对照,以及来自芬兰的144例散发性PD患者和135例对照中,评估了四个双等位基因多态性的等位基因、基因型和单倍型频率。
在所研究的任何人群中均未发现关联。
综上所述,这些发现表明,至少在一些欧洲人群中,FGF20中的常见基因变异不是PD的危险因素。