精神分裂症患者与正常对照者大脑中的脂肪酸水平。

Fatty acid levels in the brains of schizophrenics and normal controls.

作者信息

Horrobin D F, Manku M S, Hillman H, Iain A, Glen M

机构信息

Efamol Research Institute, Kentville, Nova Scotia, Canada.

出版信息

Biol Psychiatry. 1991 Oct 15;30(8):795-805. doi: 10.1016/0006-3223(91)90235-e.

DOI:10.1016/0006-3223(91)90235-e

PMID:1751622

Abstract

Essential fatty acids are important constituents of the brain. There is evidence that levels in blood of certain essential fatty acids and their eicosanoid derivatives may be abnormal. We now report that in the frontal cortex of schizophrenic patients there are significant differences from normal in the fatty acid composition of phosphatidylethanolamine. These differences from normal were not found in the cerebellar cortex.

摘要

必需脂肪酸是大脑的重要组成部分。有证据表明，某些必需脂肪酸及其类二十烷酸衍生物的血液水平可能异常。我们现在报告，在精神分裂症患者的额叶皮质中，磷脂酰乙醇胺的脂肪酸组成与正常情况存在显著差异。在小脑皮质中未发现与正常情况的这些差异。