Nasrallah H A, Schwarzkopf S B, Olson S C, Coffman J A
Dept. of Psychiatry, Ohio State University College of Medicine, Columbus 43210.
Schizophr Bull. 1990;16(2):205-10. doi: 10.1093/schbul/16.2.205.
There are many reports of clinical and biological gender differences in schizophrenia. Gender differences in structural brain abnormalities in schizophrenia have been reported on both computed tomographic (CT) and magnetic resonance imaging (MRI) scans. We present here a new MRI study of cerebral structures in schizophrenia. On the basis of previous findings, we hypothesized that schizophrenic males are more likely than females to show smaller brains and larger ventricles compared to their control counterparts. Our results indicated that the opposite was true: schizophrenic females, but not schizophrenic males, had smaller craniums and brains and larger lateral and third ventricles on MRI scans. The possible significance and implications of these data are discussed.
有许多关于精神分裂症临床和生物学性别差异的报告。在计算机断层扫描（CT）和磁共振成像（MRI）扫描中均有关于精神分裂症大脑结构异常性别差异的报道。我们在此展示一项关于精神分裂症大脑结构的新MRI研究。基于先前的研究结果，我们假设与对照组相比，精神分裂症男性比女性更有可能出现脑容量较小和脑室较大的情况。我们的结果表明事实恰恰相反：在MRI扫描中，精神分裂症女性而非男性，颅骨和脑容量较小，侧脑室和第三脑室较大。本文讨论了这些数据可能具有的意义和影响。
