DeMyer M K, Gilmor R L, Hendrie H C, DeMyer W E, Augustyn G T, Jackson R K
Institute of Psychiatric Research, Indianapolis, IN 46223.
Schizophr Bull. 1988;14(1):21-37. doi: 10.1093/schbul/14.1.21.
Evidence from computerized tomography (CT) suggests that schizophrenic patients may have smaller brains than normal subjects. Magnetic resonance imaging (MRI), which produces more clearly defined images than CT, was used to measure T1 and brain size of 24 schizophrenic and 24 normal subjects matched for age and sex but not for education. Two transverse images were obtained: slice 1 at the foramina of Monro and slice 2 at the widest part of the lateral ventricles. Adequate T1 instrumental reliability could not be demonstrated. Schizophrenic subjects had smaller right hemispheres (slice 1) and smaller frontal areas (slice 2) than normal subjects. However, when education was taken into account, only the left frontal area (slice 2) was smaller in schizophrenic than in normal subjects. Larger brain areas were associated with better cognitive test scores and fewer neurological signs. Cranial and body size were similar in both diagnostic groups.
计算机断层扫描（CT）的证据表明，精神分裂症患者的大脑可能比正常人小。磁共振成像（MRI）能产生比CT更清晰的图像，被用于测量24名精神分裂症患者和24名年龄、性别匹配但教育程度不匹配的正常受试者的T1和脑容量。获取了两张横向图像：一张是在Monro孔处的切片1，另一张是在侧脑室最宽处的切片2。无法证明T1仪器的可靠性足够。精神分裂症患者的右半球（切片1）和额叶区域（切片2）比正常受试者小。然而，考虑到教育程度后，只有精神分裂症患者的左额叶区域（切片2）比正常受试者小。较大的脑区与更好的认知测试分数和更少的神经体征相关。两个诊断组的颅骨和身体大小相似。
