Woods B T, Kinney D K, Yurgelun-Todd D A
Department of Neurology, McLean Hospital, Belmont, MA 02178.
Biol Psychiatry. 1991 Oct 15;30(8):806-16. doi: 10.1016/0006-3223(91)90236-f.
Previous research found schizophrenics to have significantly more neurological signs than normal controls, even when signs were screened to exclude possible artifacts, and limited to "hard" signs of localizing significance. Schizophrenics with a family history of psychosis also tended to have more neurological signs than those without such a history. The present study examined whether these findings could be confirmed in new samples of schizophrenics and controls, using interview-based DSM-III and DSM-III-R diagnoses. Schizophrenics had significantly more hard signs than controls, and schizophrenics with a family history for psychosis again had more signs than those without this history. When present study data were analyzed alone, as well as when pooled with data from previous research using similar methods, hard signs were significantly greater in both (a) schizophrenics versus controls and (b) schizophrenics with versus without a family history of psychosis, supporting the hypothesis that neurological signs reflect a significant etiologic factor in schizophrenia.
先前的研究发现，即使对体征进行筛选以排除可能的假象，并将其限定为具有定位意义的“硬性”体征，精神分裂症患者的神经体征仍显著多于正常对照组。有精神病家族史的精神分裂症患者往往也比没有这种病史的患者有更多的神经体征。本研究使用基于访谈的DSM-III和DSM-III-R诊断方法，检验了这些发现能否在新的精神分裂症患者和对照组样本中得到证实。精神分裂症患者的硬性体征显著多于对照组，有精神病家族史的精神分裂症患者再次比没有这种病史的患者有更多的体征。当单独分析本研究数据以及将其与使用类似方法的先前研究数据合并时，（a）精神分裂症患者与对照组相比以及（b）有与没有精神病家族史的精神分裂症患者相比，硬性体征均显著更多，这支持了神经体征反映精神分裂症中一个重要病因因素的假设。
