Goldstein G, Zubin J
Highland Drive VA Medical Center, Pittsburgh, PA 15026.
Schizophr Res. 1990 Mar-Apr;3(2):117-26. doi: 10.1016/0920-9964(90)90044-8.
Age differences among 134 schizophrenics with associated neurological dysfunction, 160 schizophrenics without such dysfunction, 285 nonschizophrenics with neurological dysfunction and 240 patient controls on the Halstead-Reitan neuropsychological Test Battery (HRB) were examined by splitting subjects at their median ages and performing two way analyses of variance for each HRB component test with diagnosis and age category as the independent variables. In the case of the schizophrenics with neurological dysfunction, significant interactions were found for several subtests of the Wechsler Adult Intelligence Scale (WAIS), and for the Speech Perception, Trail Making and Aphasia Screening Test. In the case of the neurologically intact subgroup, significant interactions were only found for the WAIS Comprehension subtest and Part B of the Trail Making Test. Only WAIS Comprehension produced a significant interaction in the nonschizophrenic group with neurological dysfunction. It was concluded that age differences in neurologically intact schizophrenics were generally comparable to those found in the controls, but that was less the case for the neurologically impaired schizophrenics. Furthermore, this pattern of findings is unlikely to be based upon the presence of associated neurological dysfunction alone, but probably reflects the particularly detrimental effect of compounding schizophrenia with neurological dysfunction.
对134名伴有神经功能障碍的精神分裂症患者、160名无此类功能障碍的精神分裂症患者、285名有神经功能障碍的非精神分裂症患者以及240名患者对照者进行了霍尔斯特德 - 雷坦神经心理测试组（HRB）测试。以年龄中位数为界将受试者分组，并以诊断和年龄类别作为自变量，对每个HRB分量表进行双向方差分析，以此研究年龄差异。在伴有神经功能障碍的精神分裂症患者中，韦氏成人智力量表（WAIS）的几个分测验、言语感知、连线测验和失语症筛查测验发现了显著的交互作用。在神经功能正常的亚组中，仅在WAIS理解分测验和连线测验B部分发现了显著的交互作用。在有神经功能障碍的非精神分裂症组中，只有WAIS理解分测验产生了显著的交互作用。研究得出结论，神经功能正常的精神分裂症患者的年龄差异通常与对照组相当，但神经功能受损的精神分裂症患者情况则并非如此。此外，这种研究结果模式不太可能仅基于相关神经功能障碍的存在，而可能反映了精神分裂症与神经功能障碍叠加所产生的特别有害的影响。
