Wykretowicz Andrzej, Adamska Karolina, Krauze Tomasz, Guzik Przemyslaw, Szczepanik Adam, Rutkowska Agnieszka, Wysoki Henryk
Division of Cardiology-Intensive Therapy, Department of Internal Medicine, University School of Medicine, Poznan, Poland.
Free Radic Res. 2007 Jun;41(6):645-9. doi: 10.1080/10715760701236741.
Oxidative stress plays an important role in the pathogenesis of atherosclerosis. Advanced oxidation protein products (AOPP) are markers of oxidative stress and mediators of inflammation. Increased arterial stiffness is associated with increased risk of cardiovascular mortality and morbidity. The aim of this study was to evaluate the relationship between an indirect marker of arterial stiffness and the AOPP level in apparently healthy individuals.
Arterial stiffness was estimated with the use of the stiffness index (SI(DVP)) which significantly correlated with age, mean blood pressure, body fat content and AOPP. The SI(DVP) was associated with AOPP concentration in both single (R = 0.22, p = 0.03) and multiple regression models adjusted for age, sex, mean blood pressure and body fat content (R(2) = 42%, p < 0.0001).
The AOPP concentration is elevated in healthy people with increased values of stiffness index. This finding supports the concept that oxidative stress may contribute to arterial stiffening in humans.
氧化应激在动脉粥样硬化的发病机制中起重要作用。晚期氧化蛋白产物（AOPP）是氧化应激的标志物和炎症介质。动脉僵硬度增加与心血管疾病死亡率和发病率增加相关。本研究的目的是评估表面健康个体中动脉僵硬度的间接标志物与AOPP水平之间的关系。
使用僵硬度指数（SI(DVP)）评估动脉僵硬度，该指数与年龄、平均血压、体脂含量和AOPP显著相关。在单因素（R = 0.22，p = 0.03）以及调整了年龄、性别、平均血压和体脂含量的多因素回归模型中（R² = 42%，p < 0.0001），SI(DVP)均与AOPP浓度相关。
僵硬度指数升高的健康人群中AOPP浓度升高。这一发现支持氧化应激可能导致人类动脉僵硬的观点。
