Mantareva Vanya, Kussovski Veselin, Angelov Ivan, Borisova Ekaterina, Avramov Latchezar, Schnurpfeil Günter, Wöhrle Dieter
Institute of Organic Chemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev str, Bl. 9, 1113 Sofia, Bulgaria.
Bioorg Med Chem. 2007 Jul 15;15(14):4829-35. doi: 10.1016/j.bmc.2007.04.069. Epub 2007 May 6.
Photodynamic activity of tetrakis-(3-methylpyridyloxy)- and tetrakis-(4-sulfophenoxy)-phthalocyanine zinc(II) toward the gram-positive Staphylococcus aureus, the gram-negative Pseudomonas aeruginosa, and the fungi Candida albicans was studied. The drug uptake dependency with an inverse behavior to the cell density was observed. The cationic photosensitizer completely inactivated S. aureus and C. albicans, and with 4 log10 P. aeruginosa. The photoinactivation at mild experimental conditions, such as drug dose of 1.5 microM and fluence of 50 mW cm(-2) for 10 min irradiation time, was shown.
研究了四（3-甲基吡啶氧基）-和四（4-磺基苯氧基）-酞菁锌（II）对革兰氏阳性金黄色葡萄球菌、革兰氏阴性铜绿假单胞菌和真菌白色念珠菌的光动力活性。观察到药物摄取依赖性与细胞密度呈反比关系。阳离子光敏剂使金黄色葡萄球菌和白色念珠菌完全失活，并使铜绿假单胞菌减少4个对数级。结果表明，在温和的实验条件下，如药物剂量为1.5微摩尔、光通量为50毫瓦/平方厘米、照射时间为10分钟时，可实现光灭活。
